Nov 14, 1998

Spermatogenesis as a model system for developmental analysis of regulatory mechanisms associated with tissue-specific gene expression

Seminars in Cell & Developmental Biology
John R McCarrey

Abstract

Spermatogenesis is a complex system leading to the formation of male gametes. Development of the spermatogenic cell lineage occurs throughout most of the pre- and post-natal lifetime of male mammals, and involves progression through a well-characterized series of stages and cell types. This progression is based on programmed gene expression. The mechanisms by which this tissue-, cell-type, and developmental-stage specific gene expression is regulated form the focus of an active area of investigation. In this review, I will summarize our efforts to elucidate these mechanisms through molecular analyses of the uniquely accessible mouse spermatogenic cell lineage.

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Mentioned in this Paper

Tissue Specificity
Tissue-Specific Gene Expression
Gene Expression
Gametes
Spermatogenesis
Spermiogenesis
Cell Type
Gene Expression Regulation, Developmental
Disease Progression
Spermatogenic Cell

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