PMID: 9182860Jan 1, 1997Paper

Spermatogenesis in the vitamin A-deficient rat: possible interplay between retinoic acid receptors, androgen receptor and inhibin alpha-subunit

The Journal of Steroid Biochemistry and Molecular Biology
Y H ZhuangP Tuohimaa

Abstract

In order to understand the mechanisms of retinol action on the testis, testicular retinoic acid receptor alpha, beta(RAR alpha and beta), androgen receptor (AR) and inhibin alpha-subunit were studied in normal, vitamin A-deficient (VAD) and vitamin A-supplemented rats by immunohistochemistry and immunoblotting. Compared to the normal testis, expression of 110 K AR was up-regulated by vitamin A withdrawal, whereas 51 K RAR alpha remained unchanged. An additional 55 K RAR alpha signal was observed. Readministration of retinol caused a marked decrease of AR in the VAD testis. By 24 h, AR declined to below the normal level. Although the 51 K RAR alpha signal remained unchanged, the 55 K band was slightly up-regulated at 6 h after retinol administration. A 51 K RAR beta protein was seen in the VAD but in not the normal testis. The intensity of the 51 K RAR beta band remained constant before and after the administration of retinol, but it had a slight up-shift at 6 h after retinol injection, suggesting post-translational modification of the receptor. The inhibin alpha-subunit of 18 K protein was undetectable in the VAD testis and increased to above normal level at 24 h after retinol administration. Immunohistochemically, nuclear AR i...Continue Reading

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Citations

May 10, 2008·Briefings in Functional Genomics & Proteomics·Xiaofeng Ye, Reuben Lotan
Oct 9, 2007·Fertility and Sterility·Kuo-Chung LanKo-En Huang
Sep 24, 2005·Molecular and Cellular Biochemistry·Daniel Pens GelainJosé Cláudio Fonseca Moreira
Feb 5, 2021·Frontiers in Cell and Developmental Biology·Mateus C AdolfiManfred Schartl

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