Spermatogonial differentiation in juvenile spermatogonial depletion (jsd) mice with androgen receptor or follicle-stimulating hormone mutations

Endocrinology
Gunapala ShettyMarvin L Meistrich

Abstract

The jsd mice experience a single wave of spermatogenesis, followed by an arrest of spermatogenesis because of a block in spermatogonial differentiation. Previous pharmacological and surgical studies have indicated that testosterone (T) and low scrotal temperatures but not FSH block spermatogonial differentiation in jsd mice. We sought to test these observations by genetic approaches by producing male jsd mutant mice with either defective androgen receptor (AR, Tfm mutation) or a deficiency of FSH (fshb(-/-)). In adult jsd-Tfm double-mutant mice, the tubule differentiation index was 95% compared with 14% in jsd littermates, suggesting that general ablation of AR function restored spermatogonial differentiation in jsd mice. The results indicated that this enhancement of differentiation was primarily a result of elevation of temperature caused by the cryptorchid position of the testis in jsd-Tfm double-mutant mice, which resulted from the lack of AR in the gubernaculum. The low levels of T were not a factor in the release of the spermatogonial differentiation block in the jsd-Tfm mice, but we were unable to determine whether inactivation of AR in the adult jsd testis had a direct effect on the restoration of spermatogonial differe...Continue Reading

References

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Citations

Jun 30, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Gensheng WangMarvin L Meistrich
Apr 21, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Guido VerhoevenKarel De Gendt
Apr 24, 2007·Reproductive Biology and Endocrinology : RB&E·Richard Ivell
May 3, 2012·Reproduction : the Official Journal of the Society for the Study of Fertility·Jose R Rodriguez-SosaIna Dobrinski
Apr 28, 2009·International Journal of Andrology·A WillemsG Verhoeven
Nov 19, 2013·Biochimica Et Biophysica Acta·Samuel B Sondalle, Susan J Baserga
Jun 14, 2021·Seminars in Cell & Developmental Biology·Paul S Cooke, William H Walker

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