Spermidine-induced improvement of memory involves a cross-talk between protein kinases C and A

Journal of Neurochemistry
Gustavo Petri GuerraMaribel Antonello Rubin

Abstract

Spermidine (SPD) is an endogenous aliphatic amine with polycationic structure that modulates NMDA receptor activity and improves memory. Recent evidence suggests that cAMP-dependent protein kinase (PKA) and cAMP response element-binding protein (CREB) play a role in SPD-induced improvement of memory. In the current study, we determined whether the calcium-dependent protein kinase (PKC) signaling pathway is involved in SPD-induced facilitation of memory of inhibitory avoidance task in adult rats. The post-training administration of the PKC inhibitor, 3-[1-(dimethylaminopropyl)indol-3-yl]-4-(indol-3-yl)maleimide hydrochloride [GF 109203X, 2.5 ρmol, intrahippocampal (ih)] with SPD (0.2 nmol, ih) prevented memory improvement induced by SPD. Intrahippocampal administration of SPD (0.2 nmol) facilitated PKC phosphorylation in the hippocampus, 30 min after administration. GF 109203X prevented not only the stimulatory effect of SPD on PKC but also PKA and CREB phosphorylation. These results suggest that memory enhancement induced by the ih administration of SPD involves the cross-talk between PKC and PKA/CREB, with sequential activation of PKC and PKA/CREB pathways, in rats.

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Citations

Jun 13, 2013·Journal of Pharmaceutical Sciences·Rita López-CebralAlejandro Sanchez
Mar 13, 2016·Neurobiology of Learning and Memory·Cristiane SignorMaribel A Rubin
Mar 27, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Gustavo Petri GuerraCarlos Fernando Mello
Jan 13, 2015·Journal of Neuroinflammation·Pâmella Karina Santana FrühaufMaribel Antonello Rubin
Mar 31, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Lucas Almeida RigoRuy Carlos Ruver Beck
Mar 19, 2014·European Journal of Pharmacology·Cristiane SignorMaribel A Rubin
May 2, 2013·Neurobiology of Learning and Memory·Daniela Aymone RibeiroMaribel Antonello Rubin
Dec 23, 2014·Ageing Research Reviews·Donald K Ingram, George S Roth
Jun 30, 2019·Alzheimer's Research & Therapy·Leslie A Sandusky-BeltranDaniel C Lee
Feb 16, 2021·The Journal of Clinical Investigation·Leslie A Sandusky-BeltranDaniel C Lee
Jul 3, 2021·Medical Sciences : Open Access Journal·Narashans Alok SagarSunil Sharma
Dec 17, 2015·Learning & Memory·Bruna Amanda GirardiMaribel Antonello Rubin

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