Spermidine synthase is prominently expressed in the striatal patch compartment and in putative interneurones of the matrix compartment

Journal of Neurochemistry
M KraussG Laube

Abstract

The ubiquitous polyamines spermidine and spermine are known as modulators of glutamate receptors and inwardly rectifying potassium channels. They are synthesized by a set of specific enzymes in which spermidine synthase is the rate-limiting step catalysing the formation of the spermine precursor spermidine from putrescine. Spermidine and spermine were previously localized to astrocytes, probably reflecting storage rather than synthesis in these cells. In order to identify the cellular origin of spermidine and spermine synthesis in the brain, antibodies were raised against recombinant mouse spermidine synthase. As expected, strong spermidine synthase-like immunoreactivity was obtained in regions known to express high levels of spermidine and spermine, such as the hypothalamic paraventricular and supraoptic nuclei. In the striatum, spermidine synthase was found in neurones and the neuropil of the patch compartment (striosome) as defined by expression of the micro opiate receptor. The distinct expression pattern of spermidine synthase, however, only partially overlapped with the distribution of the products spermidine and spermine in the striatum. In addition, spermidine synthase-like immunoreactivity was seen in patch compartment...Continue Reading

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Citations

Dec 7, 2013·Journal of Biophysics·V MakarovM Inyushin
Dec 3, 2014·The Psychiatric Clinics of North America·Serguei N SkatchkovMisty Eaton
Oct 31, 2014·Scientific Reports·Miki HiasaYoshinori Moriyama
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Feb 19, 2020·Molecular Membrane Biology·Jia LiuWei Zou
Sep 12, 2018·Biomolecules·Saif Shahriar Rahman NirzhorSharmind Neelotpol
Jan 28, 2010·Cancer Prevention Research·TachaZi Plym ForshellJonas A Nilsson

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