Spermine inhibits Endoplasmic Reticulum Stress-induced Apoptosis: a New Strategy to Prevent Cardiomyocyte Apoptosis

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Can WeiChangqing Xu

Abstract

Endoplasmic reticulum stress (ERS) plays an important role in the progression of acute myocardial infarction (AMI), in part by mediating apoptosis. Polyamines, including putrescine, spermidine, and spermine, are polycations with anti-oxidative, anti-aging, and cell growth-promoting activities. This study aimed to determine the mechanisms by which spermine protects against ERS-induced apoptosis in rats following AMI. AMI was established by ligation of the left anterior descending coronary artery (LAD) in rats, and exogenous spermine was administered by intraperitoneal injection (2.5 mg/ml daily for 7 days pre-AMI). Spermine treatment limited infarct size, attenuated cardiac troponin I and creatinine kinase-MB release, improved cardiac function, and decreased ERS and apoptosis related protein expression. Isolated cardiomyocytes subjected to hypoxia showed significant increase in reactive oxygen species (ROS) and the expression of apoptosis and ERS related proteins; these effects occurred through PERK and eIF2α phosphorylation. The addition of spermine attenuated cardiomyocyte apoptosis, suppressed the production of ROS, and inhibited ERS related pathways. Spermine was an effective pre-treatment strategy to attenuate cardiac ERS i...Continue Reading

Citations

Feb 3, 2018·Oxidative Medicine and Cellular Longevity·Fengmei XingJinkun Xi
Jan 27, 2018·Science·Frank MadeoGuido Kroemer
May 17, 2018·International Journal of Molecular Medicine·Hong-Xu JinSu-Nuan Zhao
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yun AiNing Zhang
Jun 30, 2021·Cancer Letters·Ita Novita SariHyog Young Kwon

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