PMID: 8953565Dec 1, 1996Paper

Spermine partially normalizes in vivo antioxidant defense potential in certain brain regions in transiently hypoperfused rat brain

Neurochemical Research
R FarbiszewskiE Skrzydlewska

Abstract

Activities of the antioxidant enzymes such as superoxide dismutase (Cu,Zn-SOD), glutathione peroxidase (GSH-Px), glutathione reductase (GSSG-R) as well as the level of reduced glutathione and the concentration of thiobarbituric acid-reactive substance (TBARS) in brain regions in transiently hypoperfused rat brain with or without intravenous infusion of spermine were evaluated. Cerebral hypoperfusion was induced by temporary occlusion of common carotid arteries for 30 min and subsequently, by reperfusion for 60 min. Infusion of spermine reversed the decrease in SOD activity in the cerebral cortex, striatum, hippocampus, hypothalamus and midbrain, and amounted to 50.1 U, 61.5 U, 50.3 U, 30.0 U, 38.0 U, respectively, while GSH-Px restored to normal values only in the cerebral cortex and striatum and amounted to 100 U and 110 U, respectively. During hypoperfusion/reperfusion and after use of spermine no changes in GSSG-R were seen in the hypothalamus and midbrain. The activity of GSSG-R was in accordance with the control for the striatum and amounted to 39.0 IU after using spermine. GSH content returned to normal values in the striatum and midbrain after i.v. use of spermine and amounted to 210 and 240 nmol/g of wet tissue, respect...Continue Reading

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Citations

Feb 27, 2001·Journal of Neuroscience Research·S M YatinD A Butterfield
Sep 24, 2009·Journal of Enzyme Inhibition and Medicinal Chemistry·Dimitra Hadjipavlou-LitinaDionissios Papaioannou
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Aug 19, 2005·The International Journal of Biochemistry & Cell Biology·Monika MozdzanDariusz Nowak
Apr 2, 2013·Biochimie·Dimitra Hadjipavlou-LitinaDionissios Papaioannou
Oct 13, 2018·International Journal of Molecular Sciences·Kuniyasu Soda

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