Jan 1, 1996

Spermine prevent iron accumulation and depress lipofuscin accumulation in cultured myocardial cells

Free Radical Biology & Medicine
M R Marzabadi, E Lłvaas

Abstract

The present work demonstrates that spermine prevents aging in cultured myocytes exposed to oxidative stress. It is found that physiological levels of spermine reduce lipofuscin accumulation with 20%, and that the antioxidative effect compares with vitamin E. By autometallography we also demonstrate that spermine prevent accumulation of free iron in the myocytes, probably by acting as a chelating agent. The effect compares to that of deferoxamine. These data provide additional insight into the antioxidative mechanism of spermine, and suggest that spermine may prevent diseases related to the Fenton reaction, as well as retard aging reactions.

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Mentioned in this Paper

Desferal
Iron Chelating Agents
Muscle Cells
Antioxidant Effect
Vitamin E Assay
Myocardium
Deferoxamine
Oxidative Stress
Chelating Agents
Oxidative Stress Analysis

About this Paper

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