Abstract
Investigations on the effect of normal healthy ageing on the muscarinic system have shown conflicting results. Also, in vivo determination of muscarinic receptor binding has been hampered by a lack of subtype selective ligands and differences in methods used for quantification of receptor densities. Recent in vitro and in vivo work with the muscarinic antagonist (R,R)-I-QNB indicates this ligand has selectivity for m(1) and m(4) muscarinic receptor subtypes. Therefore, we used (R,R)[(123)I]-I-QNB and single photon emission tomography to study brain m(1) and m(4) muscarinic receptors in 25 healthy female subjects (11 younger subjects, age range 26-32 years and 14 older subjects, age range 57-82 years). Our aims were to ascertain the viability of tracer administration and imaging within the same day, and to evaluate whether normalization to whole brain, compared to normalization to cerebellum, could alter the clinical interpretation of results. Images were analyzed using the simplified reference tissue model and by two ratio methods: normalization to whole brain and normalization to cerebellum. Significant correlations were observed between kinetic analysis and normalization to cerebellum, but not to whole brain. Both the kinetic...Continue Reading
References
Jan 1, 1992·The Journal of Neuropsychiatry and Clinical Neurosciences·D R WeinbergerT N Chase
Jan 1, 1992·Journal of Neuroscience Research·A NordbergB Winblad
Dec 1, 1990·Journal of Neuroscience Research·E Giacobini
Apr 1, 1986·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D F WongH N Wagner
Jan 1, 1987·Neuroscience·R CortésJ M Palacios
Aug 1, 1970·British Journal of Psychology·M Annett
Feb 1, 1994·The European Journal of Neuroscience·F van HuizenC Shaw
Jan 12, 1993·Neuroscience Letters·T SuharaY Tateno
Mar 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K S LeeD E Kuhl
Apr 1, 1997·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·B R ZeebergR C Reba
Dec 1, 1996·NeuroImage·A A Lammertsma, S P Hume
Jun 28, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·T J RaedlerD R Weinberger
Feb 13, 2001·Synapse·J K ZubietaD E Kuhl
Sep 26, 2002·Journal of Chemical Neuroanatomy·Margaret PiggottElaine Perry
Dec 31, 2002·The American Journal of Psychiatry·Thomas J RaedlerDaniel R Weinberger
Jan 31, 2003·Synapse·Teresa A PodruchnyRobert M Cohen
Jun 12, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Thomas J RaedlerDaniel R Weinberger
Jul 26, 2003·NeuroImage·J D GispertM Desco
Jul 26, 2003·NeuroImage·Kjell ErlandssonLyn S Pilowsky
Jan 1, 1995·IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society·K Lange, J A Fessler
Citations
Mar 23, 2007·Der Urologe. Ausg. A·M Goepel, K-C Steinwachs
Apr 27, 2013·Zeitschrift für Gerontologie und Geriatrie·K BecherM Wehling
Dec 19, 2006·Hormones and Behavior·Ray NorburyDeclan G M Murphy
Jan 27, 2011·British Journal of Clinical Pharmacology·Shizuo YamadaHideo Tsukada
May 12, 2006·European Urology·Gary KayMichael Steel
Oct 1, 2011·Nuclear Medicine and Biology·Adriana Alexandre S TavaresSally L Pimlott
Feb 6, 2010·Journal of Pharmacological Sciences·Akira YoshidaShizuo Yamada
Nov 26, 2008·Nuclear Medicine and Biology·Shil Patel, Raymond Gibson
Jun 29, 2006·Home Health Care Services Quarterly·Kathleen Ell
Mar 11, 2008·The Journal of Pharmacology and Experimental Therapeutics·Shuji MaruyamaShizuo Yamada
Oct 26, 2007·Neurochemical Research·Emma TerrièreDavid Wyper
Oct 25, 2012·International Neurourology Journal·Shizuo YamadaYoshihiko Ito
Aug 26, 2010·Deutsches Ärzteblatt International·Mark GoepelHerbert Rübben
Oct 30, 2020·Frontiers in Neuroscience·Robert C ShawAdriana Alexandre S Tavares