SPET imaging of central muscarinic receptors with (R,R)[123I]-I-QNB: methodological considerations

Nuclear Medicine and Biology
Ray NorburyD G M Murphy

Abstract

Investigations on the effect of normal healthy ageing on the muscarinic system have shown conflicting results. Also, in vivo determination of muscarinic receptor binding has been hampered by a lack of subtype selective ligands and differences in methods used for quantification of receptor densities. Recent in vitro and in vivo work with the muscarinic antagonist (R,R)-I-QNB indicates this ligand has selectivity for m(1) and m(4) muscarinic receptor subtypes. Therefore, we used (R,R)[(123)I]-I-QNB and single photon emission tomography to study brain m(1) and m(4) muscarinic receptors in 25 healthy female subjects (11 younger subjects, age range 26-32 years and 14 older subjects, age range 57-82 years). Our aims were to ascertain the viability of tracer administration and imaging within the same day, and to evaluate whether normalization to whole brain, compared to normalization to cerebellum, could alter the clinical interpretation of results. Images were analyzed using the simplified reference tissue model and by two ratio methods: normalization to whole brain and normalization to cerebellum. Significant correlations were observed between kinetic analysis and normalization to cerebellum, but not to whole brain. Both the kinetic...Continue Reading

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Citations

Apr 27, 2013·Zeitschrift für Gerontologie und Geriatrie·K BecherM Wehling
Dec 19, 2006·Hormones and Behavior·Ray NorburyDeclan G M Murphy
Oct 1, 2011·Nuclear Medicine and Biology·Adriana Alexandre S TavaresSally L Pimlott
Nov 26, 2008·Nuclear Medicine and Biology·Shil Patel, Raymond Gibson
Jun 29, 2006·Home Health Care Services Quarterly·Kathleen Ell
Mar 11, 2008·The Journal of Pharmacology and Experimental Therapeutics·Shuji MaruyamaShizuo Yamada
Oct 25, 2012·International Neurourology Journal·Shizuo YamadaYoshihiko Ito
Aug 26, 2010·Deutsches Ärzteblatt International·Mark GoepelHerbert Rübben
Oct 30, 2020·Frontiers in Neuroscience·Robert C ShawAdriana Alexandre S Tavares

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