SpHbox7, a new Abd-B class homeobox gene from the sea urchin Strongylocentrotus purpuratus: insights into the evolution of hox gene expression and function

Developmental Dynamics : an Official Publication of the American Association of Anatomists
S L DobiasR E Maxson

Abstract

Hox genes, by virtue of their key functions in axial patterning, have long been thought to be pivotal players in the evolution of developmental mechanisms. Despite their potential importance in evolution, there is little information about Hox genes in animal groups that are most closely related to ancestral Chordates. Accordingly, we have taken the step of analyzing Hox gene expression and function in the sea urchin embryo, whose simple bilateral body plan is thought to resemble that of a stem organism in the Chordate lineage. Here we describe the isolation, sequences analysis and spatiotemporal expression pattern of a sea urchin (Strongylocentrotus purpuratus) Abd-B-like gene, designated SpHbox7. We show that this gene is one of at least two Abd-B-like genes in the S. purpuratus genome, a result that argues against the simple hypothesis that Hox gene duplications occurred only during the evolution of the chordates. SpHbox7 transcripts are first detectable in midblastula stage embryos, increase in amount during gastrulation, decline slightly by the pluteus stage, and are not detectable in any tissue of the adult. Whole mount in situ hybridization and antibody staining with an SpHbox7-specific antibody reveal that both SpHbox7 m...Continue Reading

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Citations

Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·K J PetersonE H Davidson
Oct 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·C Arenas-MenaE H Davidson
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·P MartinezE H Davidson
Mar 22, 2001·Evolution & Development·K J PetersonE H Davidson
Jun 10, 2006·International Journal of Biological Sciences·Ana Sara Monteiro, David E K Ferrier
Apr 4, 2001·Development, Growth & Differentiation·T Nogi, K Watanabe
Sep 16, 2004·Development, Growth & Differentiation·Tetsuya Kominami, Hiromi Takata
Sep 12, 2006·Development, Growth & Differentiation·César Arenas-MenaEric H Davidson
Apr 2, 2014·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jun Tsuchimoto, Masaaki Yamaguchi
Oct 3, 2006·Development Genes and Evolution·Yuko HaraShonan Amemiya
Aug 24, 2005·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·R Andrew CameronLeroy Hood
May 25, 2002·Developmental Biology·Eric H DavidsonHamid Bolouri
Mar 15, 2000·Developmental Biology·K J PetersonE H Davidson

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