PMID: 15233558Jul 6, 2004Paper

Sphenoid sinus brown tumor, a mass lesion of occipital bone and hypercalcemia: an unusual presentation of primary hyperparathyroidism

Journal of Endocrinological Investigation
C EremM Telatar

Abstract

Brown tumor is a focal lesion of the bone caused by primary or, less commonly, secondary or tertiary hyperparathyroidism (HPT). While the mandible is the most frequently involved bone in the head and neck region, atypical involvement of the cranium in the area of the sphenoid sinus is exceedingly rare. In the literature, a unique case of brown tumor of the sphenoid sinus was reported in a patient with primary HPT. We present a case of sphenoid sinus and occipital bone brown tumor associated with primary HPT. A 47-yr-old woman presented a 2-yr history of headaches, dizziness, diffuse body and articular pain, fatigue, and a 6-month history of intermittent nausea and vomiting, polydipsia, and polyuria. Magnetic resonance imaging (MRI) demonstrated an expansive mass lesion in the sphenoid sinus with erosion of the sellar floor and medial wall of the right orbit, and expansion in the medulla of bone. Examination of biopsy specimens obtained from sphenoid sinus mass confirmed the diagnosis of brown tumor. The biochemical laboratory studies showed elevation of parathyroid hormone and confirmed the diagnosis of primary HPT. Excision of a parathyroid adenoma affected the metabolic status into normalizing. At the follow-up of 12 months p...Continue Reading

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Citations

Oct 3, 2014·Case Reports in Endocrinology·Abelardo Loya-SolísRené Rodríguez-Gutiérrez
Mar 14, 2007·Archives of Orthopaedic and Trauma Surgery·Manabu HoshiAkira Matsumura
Dec 24, 2011·Annales d'endocrinologie·Cécile GrégoirePierre Weinmann
Nov 22, 2011·World Neurosurgery·Kyle M FargenGregory J Velat
Nov 9, 2011·Clinical Radiology·F B ErgenG Gedikoglu
Apr 28, 2012·Hemodialysis International·Mouna HamoudaMezri Elmay
Aug 21, 2009·Clinical Nuclear Medicine·James KirkRakesh Ganatra
Aug 14, 2015·Craniomaxillofacial Trauma & Reconstruction·Érica Cristina MarchioriAlbert Thomas Indresano
Jul 31, 2019·Insights Into Imaging·Cheng XieKaren Partington
Apr 2, 2008·The Journal of Bone and Joint Surgery. British Volume·W M M Fok, H B Leung
Feb 26, 2016·World Journal of Nuclear Medicine·Rohit Kumar PhulsungaBhagwant Rai Mittal

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