Spherical aggregates of coxsackie B4 virus particles in mouse pancreas

Beiträge Zur Pathologie
J M Harb, G E Burch

Abstract

A high titer culture of Coxsackie B4 virus was used to induce pancreatitis in newborn mice. In animals sacrificed 1 or 2 days after intraperitoneal inoculation, we observed cytonecrosis consistent with picornaviral infection as well as necrosis indicative of pancreatitis. In addition, we observed aggregates of particles which seem to be Coxsackie B4 virus particles, some arranged in the typical picornaviral crystalloid lattice formation and others arranged into spherical masses approximately 102 nm in diameter. Depending upon the depth and orientation of section through the spherical aggregates, the particles were arranged into two patterns which were readily distinguishable. When the plane of section was through the center of the sphere, 10 particles circularly arranged around a dense particle core were observed. When the sphere was cut tangentially, the particles were arranged in a zig-zag pattern so that there were two concentric layers of at least 6 particles per layer, with no central core. Both crystalloid and spherical aggregates were observed free within acinocyte cytoplasm, and within autophagic vacuoles, cytosegresomes, and fine granular bodies of acinocytes, and within phagocytic vacuoles of macrophages. We conclude ...Continue Reading

References

Oct 1, 1971·Cardiovascular Research·C Y TsuiJ M Harb
Feb 1, 1973·Journal of Molecular and Cellular Cardiology·J M Harb, G E Burch
Jan 1, 1974·Pathologia et microbiologia·G E BurchJ M Harb
Feb 1, 1971·Experimental and Molecular Pathology·A K HarrisonG W Gary

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Citations

Sep 24, 2010·Future Microbiology·Christopher C KemballJ Lindsay Whitton
Dec 11, 2013·Journal of Cardiovascular Translational Research·Andreas KoenigIwona A Buskiewicz
Aug 1, 1979·Experimental and Molecular Pathology·G E Burch, J M Harb
Apr 11, 2015·Virology·William T Jackson
Jul 16, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Xianbao ZhanBaoan Ji
May 1, 1975·Postgraduate Medical Journal·G E Burch
Dec 14, 2018·International Journal of Molecular Sciences·Po-Yuan Ke

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