Spherical and Worm-Like Micelles from Fructose-Functionalized Polyether Block Copolymers

Macromolecular Bioscience
Tobias C MajdanskiMichael Gottschaldt

Abstract

This paper presents the synthesis and characterization of d-fructose modified poly(ethylene glycol) (Fru-PEG) and fructose modified poly(ethylene glycol)-block-poly(ethyl hexyl glycidyl ether) (Fru-PEG-b-PEHG) that are both prepared by initiation with isopropyliden protected fructose, followed by deprotection of the sugar. The block copolymers are self-assembled into micelles, and are subsequently characterized by cryo-TEM and dynamic light scattering. The fluorescent dye Nile red is encapsulated as a model hydrophobic compound and fluorescent marker to perform initial uptake tests with breast cancer cells. The uptake of sugar and nonsugar decorated micelles is compared.

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Citations

Feb 9, 2021·Biomacromolecules·Johanna K ElterFelix H Schacher

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