PMID: 11321656Apr 26, 2001Paper

Sphincter-conserving treatment of carcinomas of the anal margin

Acta Oncologica
S BieriJ M Kurtz

Abstract

Between April 1982 and December 1997 24 patients with carcinoma of the anal margin were treated with radiation therapy (RT) (10 patients) or RT-chemotherapy (CT) (14 patients). External beam RT (EBRT) was delivered in 18 patients, combined with brachytherapy in 5 patients, while one patient was treated with brachytherapy alone. Inguinal nodes were irradiated in 17 patients. Chemotherapy was based on 5-fluorouracil and mitomycin-C. At 5 years, the overall survival rate was 56% and the locoregional rate was 69.5%. Anal sphincter was preserved in 16/24 treated patients. Grade 4 late complications were observed in 3 patients. This study reinforces the notion that radical RT +/- CT provides a high probability of cure and sphincter preservation in patients presenting with this rare condition. Major late toxicity is uncommon; a better adaptation of treatment technique to the individual clinical situation may prevent some of the more severe complications in the future.

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Oct 6, 2001·Sexually Transmitted Infections·F Martin, M Bower
Jan 9, 2003·The Surgical Clinics of North America·Harvey G Moore, José G Guillem
Apr 28, 2004·Journal of Surgical Oncology·Heather E NewlinWilliam M Mendenhall
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Oct 1, 2010·American Journal of Clinical Oncology·Christopher J BalamuckiWilliam M Mendenhall
May 15, 2012·Current Opinion in Oncology·Yixing Jiang, Jaffer A Ajani

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