PMID: 11900684Mar 20, 2002Paper

Sphincter of Oddi dysfunction: is there a role for medical therapy?

Current Gastroenterology Reports
A G Craig, James Toouli

Abstract

If the mechanism of pain in patients with sphincter of Oddi (SO) dysfunction is functional obstruction of the biliary tract, and at least in some patients it results from sphincter smooth muscle hypertrophy, then smooth muscle relaxants should have a theoretic role in the management of these patients. Calcium channel antagonists and other smooth muscle relaxants have been shown in "acute" manometric studies to alter SO motility. However, the effect of these agents on vascular smooth muscle remains a concern and often limits their use. At present the role of medical therapy is somewhat unclear because few well-conducted studies have used manometric criteria for the diagnosis of SO dysfunction and the selection of patients for therapy. The main drawback is that no drugs appear to be specific for the SO, long acting, and free of side effects.

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Citations

Jun 13, 2012·Langenbeck's Archives of Surgery·Thomas C HallGiuseppe Garcea
Mar 16, 2007·Digestive Diseases and Sciences·Antonio Bosch, Luis R Peña
Aug 7, 2009·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Cuiping LiXiaohua Hou
Jan 24, 2003·AJR. American Journal of Roentgenology·Reiji SugitaNaotaka Fujita
Nov 4, 2016·Expert Review of Gastroenterology & Hepatology·Paul R Tarnasky
Apr 17, 2004·Journal of Clinical Gastroenterology·Giuseppe PiccinniGiovanni Martino Bonomo
Jan 18, 2003·World Journal of Gastroenterology : WJG·Bao-Ying ChenXiang-Xin Yang

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