PMID: 6322900Apr 1, 1984Paper

Sphincter of Oddi motility

The British Journal of Surgery
J Toouli

Abstract

Recent developments of manometric and endoscopic instrumentation have rekindled interest in sphincter of Oddi function. As a result of human and animal studies, our understanding of normal sphincter of Oddi physiology has increased and possible motility abnormalities are being identified. Manometric studies have shown that the sphincter of Oddi is characterized by prominent phasic contractions which are super-imposed on a low tonic pressure. The phasic contractions are orientated mainly in an antegrade direction; however, both simultaneous and retrograde contractions are registered. Cineradiography has demonstrated that the phasic contractions have a propulsive function, expelling small volumes of fluid from the common bile duct into the duodenum. Intravenously administered cholecystokinin-octapeptide normally inhibits the phasic contractions and reduces the sphincter tone. Motility abnormalities may occur if the sphincter of Oddi exhibits abnormally high tone, alteration in the direction of the phasic contractions, abnormal changes in the contraction frequency, or abnormal responses to hormonal stimulation. Preliminary human studies demonstrate disorders in sphincter of Oddi motility patterns, suggesting that motility abnormal...Continue Reading

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Citations

May 1, 1992·Digestive Diseases and Sciences·K F BinmoellerJ P Delmont
Oct 1, 1991·Digestive Diseases and Sciences·A ThuneJ Toouli
Feb 1, 1992·Digestive Diseases and Sciences·H Meshkinpour, M Mollot
Mar 13, 2003·Current Gastroenterology Reports·Hans-Dieter Allescher
Jan 1, 1988·Pharmacology & Therapeutics·H C McKirdy
Jul 1, 1989·Journal of Gastroenterology and Hepatology·J N Baxter
Nov 1, 1989·Journal of Gastroenterology and Hepatology·J IannosJ Toouli
May 1, 1990·Gut·P A GraceR C Williamson
Dec 24, 1998·Gut·J W ChenJ Toouli
Jun 1, 1991·Baillière's Clinical Gastroenterology·J Toouli
Oct 1, 1987·Scandinavian Journal of Gastroenterology·A Lasson
Apr 1, 1988·Scandinavian Journal of Gastroenterology·A LassonB Zederfeldt
Jan 1, 1989·Biomaterials, Artificial Cells, and Artificial Organs·K L Cox, A T Cheung
Dec 1, 1990·Archives internationales de physiologie et de biochimie·M J PozoJ A Madrid
Oct 1, 1989·The Australian and New Zealand Journal of Surgery·M C EatonJ Toouli
Jul 1, 1989·The British Journal of Surgery·C S WorthleyJ Toouli
May 23, 2015·Der Internist·H-D Allescher
Jul 21, 2016·Digestive Diseases and Sciences·Tilak ShahMitchell L Schubert
Jul 1, 1987·The Journal of Surgical Research·P A GraceH A Pitt
Jul 12, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·B P Manning, G M Mawe
Feb 8, 2002·World Journal of Gastroenterology : WJG·Xin-Jiang WangXiang-Xin Yang
Feb 1, 2014·The Journal of the American Osteopathic Association·Katherine Heineman

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