Sphincter preservation following preoperative radiotherapy for rectal cancer: report of a randomised trial comparing short-term radiotherapy vs. conventionally fractionated radiochemotherapy

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Krzysztof BujkoP Kukołowicz

Abstract

The aim was to verify whether preoperative conventionally fractionated chemoradiation offers an advantage in sphincter preservation in comparison with preoperative short-term irradiation. Patients with resectable T3-4 rectal carcinoma without sphincters' infiltration and with a lesion accessible to digital rectal examination were randomised into: preoperative 5x5Gy short-term irradiation with subsequent total mesorectal excision (TME) performed within 7 days or chemoradiation to a total dose of 50.4Gy (1.8Gy per fraction) concomitantly with two courses of bolus 5-fluorouracil and leucovorin followed by TME after 4-6 weeks. Surgeons were obliged to base the type of operation on the tumour status at the time of surgery. Between 1999 and 2002, 316 patients from 19 institutions were enrolled. The sphincter preservation rate was 61% in the 5x5Gy arm and 58% in the radiochemotherapy arm, P = 0.57. The tumour was on average 1.9 cm smaller (P < 0.001) among patients treated with chemoradiation compared with short-term schedule. For patients who underwent sphincter-preserving procedure, the surgeons generally followed the rule of tailoring the resection according to tumour downsizing; the median distal bowel margin was identical (2 cm) ...Continue Reading

References

Oct 1, 1990·Diseases of the Colon and Rectum·A HornO Dahl
Jul 1, 1982·The British Journal of Surgery·R J NichollsI K Fry
Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·J D CoxT F Pajak
Feb 1, 1996·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·G J FrykholmB Glimelius
May 1, 1997·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·W GrafB Glimelius
May 20, 1998·International Journal of Radiation Oncology, Biology, Physics·B D MinskyG Hanks
Jun 2, 1998·The British Journal of Surgery·E CarlsenR J Heald
Sep 25, 1998·International Journal of Radiation Oncology, Biology, Physics·R WagmanP P Paty
Apr 14, 1999·The British Journal of Surgery·M DahlbergL Påhlman
Mar 10, 2001·International Journal of Radiation Oncology, Biology, Physics·A GrannB D Minsky
Sep 8, 2001·The New England Journal of Medicine·E KapiteijnUNKNOWN Dutch Colorectal Cancer Group
Feb 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C A M MarijnenUNKNOWN Cooperative Investigators of the Dutch Colorectal Cancer Group
Feb 19, 2002·Journal of the American College of Surgeons·Spiros P HiotisW Douglas Wong
Jun 14, 2002·International Journal of Radiation Oncology, Biology, Physics·Vincenzo ValentiniMaurizio Cosimelli
Oct 16, 2002·International Journal of Radiation Oncology, Biology, Physics·Michael DahlbergUNKNOWN Swedish Rectal Cancer Trial

❮ Previous
Next ❯

Citations

Dec 11, 2013·Current Oncology Reports·Miranda B KimJennifer Y Wo
Dec 7, 2013·International Journal of Colorectal Disease·Aristotelis TouloumtzidisBernhard J Lammers
Mar 13, 2014·International Journal of Radiation Oncology, Biology, Physics·Robert J MyersonParag Parikh
Mar 26, 2014·Journal of Cancer Research and Clinical Oncology·Julie Smith-GagenJonathan Tay
Feb 26, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Felipe A CalvoJosé L Carreras
Nov 20, 2008·Techniques in Coloproctology·A F J de BruinE van der Harst
Aug 12, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J S TsangE D Mulligan
Oct 25, 2013·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Mi-Joo ChungMi-Ryeong Ryu
Dec 5, 2014·Future Oncology·Francesco Sclafani, David Cunningham
Dec 12, 2012·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·C Rödel, G Klautke
Jan 10, 2013·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·M L Sautter-BihlR Sauer
Dec 7, 2013·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·F A CalvoE Alvarez
Jul 9, 2008·World Journal of Gastroenterology : WJG·Jochem van der Voort van ZijpMarc D Basson
Aug 1, 2007·Clinics in Colon and Rectal Surgery·Smitha S KrishnamurthiTimothy J Kinsella
Mar 30, 2010·World Journal of Surgical Oncology·Yon Kuei LimOswens S H Lo
Mar 18, 2011·World Journal of Gastroenterology : WJG·Sarah Popek, Vassiliki Liana Tsikitis
Mar 18, 2011·World Journal of Gastroenterology : WJG·Jürgen Mulsow, Des C Winter
Jan 1, 2006·The Libyan Journal of Medicine·Riyad Bendardaf
Nov 3, 2005·Nature Clinical Practice. Oncology·Lars Påhlman
Aug 14, 2012·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Binghong XiongCaiquan Zhang
Mar 27, 2007·Digestive Diseases·Louiza Vini
Nov 8, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Krzysztof BujkoUNKNOWN Polish Colorectal Study Group
Dec 8, 2007·International Journal of Colorectal Disease·Lutz MoserStefan Höcht
Dec 8, 2007·International Journal of Colorectal Disease·Anders JakobsenVagn Ove Bendtsen
Feb 18, 2009·International Journal of Colorectal Disease·Nikolaos GouvasEvaghelos Xynos
Mar 17, 2010·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Paula Manchon WalshUNKNOWN Colorectal Cancer OncoGuia Group
Oct 26, 2010·Journal of Gastrointestinal Cancer·Mark A BoccolaMatthew A Croxford
Jul 30, 2008·Annals of Surgical Oncology·Christopher G Willett, Brian G Czito
Sep 4, 2008·Annals of Surgical Oncology·Andrzej RutkowskiUNKNOWN Polish Colorectal Study Group
May 19, 2011·Annals of Surgical Oncology·Oliver C ShihabGina Brown

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