Sphingolipid signalling in the cardiovascular system: good, bad or both?

European Journal of Pharmacology
Astrid E Alewijnse, Stephan L M Peters

Abstract

Sphingolipids are biologically active lipids that play important roles in various cellular processes and the sphingomyelin metabolites ceramide, sphingosine and sphingosine-1-phosphate can act as signalling molecules in most cell types. With the recent development of the immunosuppressant drug FTY720 (Fingolimod) which after phosphorylation in vivo acts as a sphingosine-1-phosphate receptor agonist, research on the role of sphingolipids in the immune and other organ systems was triggered enormously. Since it was reported that FTY720 induced a modest, but significant transient decrease in heart rate in animals and humans, the question was raised which pharmacological properties of drugs targeting sphingolipid signalling will affect cardiovascular function in vivo. The answer to this question will most likely also indicate what type of drug could be used to treat cardiovascular disease. The latter is becoming increasingly important because of the increasing population carrying characteristics of the metabolic syndrome. This syndrome is, amongst others, characterized by obesity, hypertension, atherosclerosis and diabetes. As such, individuals with this syndrome are at increased risk of heart disease. Now numerous studies have inve...Continue Reading

References

Jan 1, 1985·Annals of the New York Academy of Sciences·H F Hoff, R E Morton
Apr 18, 1998·The Biochemical Journal·G C ZondagW H Moolenaar
Oct 9, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·S Chatterjee
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·P XiaM A Vadas
Oct 16, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·A SachinidisH Vetter
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·J IgarashiT Michel
May 9, 2000·Progress in Lipid Research·N AugéT Levade
Jul 6, 2000·The Biochemical Journal·S Pyne, N J Pyne
Mar 29, 2001·Diabetes·T Mandrup-Poulsen
Apr 20, 2001·British Journal of Pharmacology·A BischoffM C Michel
Jun 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Y OsawaH Moriwaki
Jan 5, 2002·The Journal of Biological Chemistry·Pu XiaMathew A Vadas
Jan 30, 2002·Cellular and Molecular Life Sciences : CMLS·J Ohanian, V Ohanian
Jan 30, 2002·The Journal of Biological Chemistry·Lewis R VannSheldon Milstien
Mar 8, 2002·Atherosclerosis·Jerzy-Roch NoferArnold von Eckardstein
May 11, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Zhu-Qiu JinMary O Gray
May 16, 2002·The Journal of Biological Chemistry·Yusuf A Hannun, Lina M Obeid
May 31, 2002·Pharmacological Reviews·Jerold ChunGabor Tigyi
Jun 6, 2002·The Journal of Biological Chemistry·William L Smith, Alfred H Merrill
Jun 12, 2002·Journal of Molecular and Cellular Cardiology·Sandrine LecourMichael N Sack
Jun 19, 2002·Biochimica Et Biophysica Acta·Amy H YangJerold Chun
Jun 19, 2002·Biochimica Et Biophysica Acta·Wolfgang Siess

❮ Previous
Next ❯

Citations

Apr 29, 2010·Current Atherosclerosis Reports·Kim EkroosReijo Laaksonen
Apr 29, 2010·Current Diabetes Reports·Andrew N HoofnagleAlan Chait
May 25, 2013·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Erich CosmiSanto Davide Ferrara
Jun 6, 2012·Cell Research·Changsheng Du, Xin Xie
Aug 13, 2010·Leukemia·M Z RatajczakJ Ratajczak
Nov 20, 2008·Cardiovascular Research·Joel S Karliner
Feb 24, 2009·Cardiovascular Research·Katherine Sattler, Bodo Levkau
Feb 28, 2009·Journal of Cardiovascular Pharmacology·Joel S Karliner
Oct 30, 2008·Current Opinion in Lipidology·Jannick Pétremand, Christian Widmann
May 4, 2011·Acta Physiologica·M BaranowskiJ Górski
Jul 10, 2013·Lipids in Health and Disease·Sehamuddin GaladariFaisal Thayyullathil
May 4, 2011·World Journal of Biological Chemistry·Koichi Sato, Fumikazu Okajima
Dec 5, 2012·Journal of Lipids·Samar M HammadRichard L Klein
Jun 27, 2012·Prostaglandins & Other Lipid Mediators·Bona LinkeKlaus Scholich
Jun 15, 2011·European Journal of Pharmacology·Pieter B van LoenenAstrid E Alewijnse
Mar 3, 2010·Progress in Lipid Research·Patricia GangoitiAntonio Gómez-Muñoz
Jun 13, 2009·Burns : Journal of the International Society for Burn Injuries·Xianglan LiuQiaobing Huang
Apr 21, 2009·European Journal of Pharmacology·Mariëlle C Hendriks-BalkAstrid E Alewijnse
Feb 12, 2011·British Journal of Pharmacology·Mirjam SchuchardtMarkus van der Giet
Mar 31, 2016·European Journal of Medicinal Chemistry·Martin H BolliBeat Steiner
Sep 24, 2013·Drug Discovery Today·Terhi VihervaaraReijo Laaksonen
Apr 7, 2015·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·Carlos AguiarRicardo Pacheco
Mar 20, 2015·Frontiers in Genetics·Mogens FengerJørgen Jeppesen
May 3, 2016·Organic Letters·Atsufumi NakahashiKenji Monde
Nov 8, 2016·The International Journal of Neuroscience·Scott BellistonSharon Lynch
Feb 4, 2016·Chemical Society Reviews·W J TippingA N Hulme
May 26, 2012·Journal of Vascular Research·Jacqueline OhanianVasken Ohanian
Jul 14, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·G DaumM A Reidy

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