Sphingolipid targets in cancer therapy

Molecular Cancer Therapeutics
David E ModrakDavid M Goldenberg

Abstract

Considerable progress has been made recently in our understanding of the role of ceramide in the induction of apoptotic cell death. Ceramide is produced by cancer cells in response to exposure to radiation and most chemotherapeutics and is an intracellular second messenger that activates enzymes, leading to apoptosis. Because of its central role in apoptosis, pharmacologic manipulation of intracellular ceramide levels should result in attenuation or enhancement of drug resistance. This may be achieved through direct application of sphingolipids or by the inhibition/activation of the enzymes that either produce or use ceramide. In addition, attention should be given to the subcellular location of ceramide generation, because this has been shown to affect the biological activity of sphingolipids. This review summarizes the sphingolipid biosynthetic pathway, as it relates to the identification of important targets for drug discovery, and the development of novel agents capable of enhancing chemotherapy.

References

Mar 12, 1991·Biochimica Et Biophysica Acta·M Koval, R E Pagano
Oct 1, 1969·Hoppe-Seyler's Zeitschrift für physiologische Chemie·W StoffelG Sticht
Oct 1, 1995·The Biochemical Journal·P De CeusterP P Van Veldhoven
Jun 15, 1995·Biochemical and Biophysical Research Communications·Y MiyakeT Kawasaki
May 24, 1996·The Journal of Biological Chemistry·A BielawskaY A Hannun
Jun 1, 1996·Cell Biology International·E AlbiM P Viola Magni
Sep 26, 1997·The Journal of Biological Chemistry·T I GudzC L Hoppel
Dec 16, 1997·Biochimica Et Biophysica Acta·M J Miro ObradorsD Allan
Feb 19, 2000·Biochemical and Biophysical Research Communications·D E ModrakR Blumenthal
Apr 27, 2000·The Journal of Biological Chemistry·S El BawabY A Hannun
Dec 2, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A HuwilerJ Pfeilschifter
Jan 20, 2001·The Journal of Biological Chemistry·P P RuvoloW S May
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·B J MarshJ R McIntosh
Sep 15, 2001·Free Radical Biology & Medicine·N Andrieu-AbadieT Levade
Dec 1, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·H BirbesL M Obeid
Jun 19, 2002·Biochimica Et Biophysica Acta·Dagmar Meyer zu HeringdorfKarl H Jakobs
Jul 19, 2002·Advances in Enzyme Regulation·Helene BirbesYusuf A Hannun
Oct 29, 2002·FEBS Letters·Félix M Goñi, Alicia Alonso
Jan 18, 2003·Biochimica Et Biophysica Acta·Benjamin J PettusYusuf A Hannun
Jan 18, 2003·Biochimica Et Biophysica Acta·Erich Gulbins, Heike Grassmé
Jan 18, 2003·Biochimica Et Biophysica Acta·Richard J Bleicher, Myles C Cabot
Jan 18, 2003·Biochimica Et Biophysica Acta·Michael MaceykaSarah Spiegel
Apr 5, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Peter P Ruvolo
May 14, 2004·Cellular and Molecular Life Sciences : CMLS·A M MartelliL Cocco
Jul 21, 2004·The Journal of Biological Chemistry·Edward Norris-CervettoTerry D Butters
Aug 3, 2004·Nature Reviews. Cancer·Besim Ogretmen, Yusuf A Hannun
Dec 30, 2004·The Journal of Experimental Medicine·Stuart M PitsonMathew A Vadas
Mar 10, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Aki IshikawaTakehiko Fujisawa
Apr 6, 2005·Transplantation Proceedings·G SchmidC Graeb
May 4, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Thomas C StoverMark Kester

❮ Previous
Next ❯

Citations

Nov 26, 2009·Cancer Chemotherapy and Pharmacology·Yan LiuPing Xie
Jun 17, 2010·Neuromolecular Medicine·Bill X WuYusuf A Hannun
Jul 22, 2010·Journal of Biomolecular Structure & Dynamics·Hong-Bin Shen, Kuo-Chen Chou
Oct 23, 2012·The Journal of Pharmacology and Experimental Therapeutics·Thomas H BeckhamXiang Liu
Jul 18, 2009·Molecular Cancer Research : MCR·Kristin GustafssonJenny Flygare
Dec 4, 2008·Future Lipidology·Erhard Bieberich
Nov 7, 2012·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Mariam GachechiladzeJosef Skarda
Jan 7, 2009·Journal of Cancer Research and Clinical Oncology·Eugen RuckhäberleManfred Kaufmann
Sep 15, 2006·FEBS Letters·Besim Ogretmen
Jun 1, 2007·Expert Opinion on Drug Discovery·Norman S Radin
Jan 8, 2013·Expert Opinion on Drug Metabolism & Toxicology·Young Mi KimSang Geon Kim
Sep 26, 2015·International Journal of Surgery·Kyuwhan JungSung-Eun Jung
Sep 8, 2012·Biochimica Et Biophysica Acta·David N BrindleyGabor J Tigyi
Sep 28, 2010·Trends in Biochemical Sciences·Stuart M Pitson
Aug 3, 2014·BMC Evolutionary Biology·Charissa de BekkerDavid P Hughes
Apr 7, 2009·Biochimica Et Biophysica Acta·Bill X WuYusuf A Hannun
Jul 7, 2009·Biotechnology Journal·Fatma Betul Kavun Ozbayraktar, Kutlu O Ulgen
Sep 8, 2010·BioFactors·Peter G Bradford, Atif B Awad
May 19, 2010·Journal of Applied Microbiology·M S CastroM A Manghi
May 18, 2016·ACS Medicinal Chemistry Letters·Eric J MillerDennis C Liotta
Aug 26, 2010·Biochemical Pharmacology·Susanne SchiffmannSabine Grösch
Sep 26, 2006·Biochimica Et Biophysica Acta·L Ashley Cowart, Lina M Obeid
Aug 6, 2015·Prostaglandins, Leukotrienes, and Essential Fatty Acids·P Castro-GómezJ Fontecha
Apr 25, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Zu-An ZhuYing Liu
Oct 26, 2010·Progress in Lipid Research·Gauri A Patwardhan, Yong-Yu Liu
Mar 6, 2012·Free Radical Biology & Medicine·Jaleel KizhakkayilSehamuddin Galadari
Sep 13, 2013·Cancer Biology & Therapy·Paul Dent
Sep 13, 2013·Cancer Biology & Therapy·Archana MukhopadhyayJane V Aldrich
Apr 28, 2009·Biochimica Et Biophysica Acta·Priya SrideviStephen Alexander
Aug 31, 2014·Bioorganic & Medicinal Chemistry·Adeeb El-DahshanJörg Rademann
Aug 3, 2016·Medicinal Research Reviews·Dominik Vogt, Holger Stark

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis