Sphingolipid transfer proteins defined by the GLTP-fold

Quarterly Reviews of Biophysics
Lucy MalininaRhoderick E Brown

Abstract

Glycolipid transfer proteins (GLTPs) originally were identified as small (~24 kDa), soluble, amphitropic proteins that specifically accelerate the intermembrane transfer of glycolipids. GLTPs and related homologs now are known to adopt a unique, helically dominated, two-layer 'sandwich' architecture defined as the GLTP-fold that provides the structural underpinning for the eukaryotic GLTP superfamily. Recent advances now provide exquisite insights into structural features responsible for lipid headgroup selectivity as well as the adaptability of the hydrophobic compartment for accommodating hydrocarbon chains of differing length and unsaturation. A new understanding of the structural versatility and evolutionary premium placed on the GLTP motif has emerged. Human GLTP-motifs have evolved to function not only as glucosylceramide binding/transferring domains for phosphoinositol 4-phosphate adaptor protein-2 during glycosphingolipid biosynthesis but also as selective binding/transfer proteins for ceramide-1-phosphate. The latter, known as ceramide-1-phosphate transfer protein, recently has been shown to form GLTP-fold while critically regulating Group-IV cytoplasmic phospholipase A2 activity and pro-inflammatory eicosanoid product...Continue Reading

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Citations

Aug 4, 2015·Chemistry and Physics of Lipids·Peter Mattjus
Apr 5, 2017·Annual Review of Biochemistry·Lucy MalininaRhoderick E Brown
Jul 16, 2015·Journal of Lipid Research·Susi AnheuserKonrad Sandhoff
Nov 23, 2017·Autophagy·Shrawan Kumar MishraRhoderick E Brown
Dec 15, 2018·PloS One·Anders P E BackmanPeter Mattjus
Jul 25, 2019·International Journal of Molecular Sciences·Doaa SamahaChristoph Arenz
Dec 25, 2016·The Journal of Biological Chemistry·Xiuhong ZhaiRhoderick E Brown
Jul 28, 2019·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Taki Nishimura, Christopher J Stefan
Mar 31, 2021·The Journal of Biological Chemistry·Yong-Guang GaoRhoderick E Brown
Jul 11, 2021·Cellular Signalling·Real Sumayya Abdul SattarSundeep Singh Saluja
Jan 24, 2020·Analytical Chemistry·Yong-Guang GaoRhoderick E Brown

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