Sphingolipid Turnover Turns Over the Fate of Aneuploid Cells

Trends in Genetics : TIG
Zuzana Storchová

Abstract

Aneuploidy, or unbalanced chromosome number, is a hallmark of cancer. Recently established model systems revealed that aneuploidy affects many aspects of cellular physiology, among them sphingolipid metabolism. The new finding that the proliferation of aneuploid cells depends on sphingolipid homeostasis offers an appealing opportunity for cancer treatment.

References

Jan 25, 2008·Nature Reviews. Molecular Cell Biology·Yusuf A Hannun, Lina M Obeid
Sep 21, 2010·Cell·Eduardo M TorresAngelika Amon
Sep 10, 2014·Proceedings of the National Academy of Sciences of the United States of America·Kristin A KnouseAngelika Amon
Aug 5, 2017·Cancer Research·Yun-Chi TangAngelika Amon
Nov 18, 2017·Nature Reviews. Cancer·Besim Ogretmen
Dec 28, 2017·Cell Reports·Sunyoung HwangEduardo M Torres

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