Sphingolipids in the chemoprevention of colon cancer

Frontiers in Bioscience : a Journal and Virtual Library
Eva M Schmelz

Abstract

Sphingolipids were first described more than 100 years ago by the physician Thudicum who named the fatty substance he found in brain, sphingosin. Among multiple other functions, sphingolipids are lipid messengers in the signaling pathways of growth factors, cytokines, cellular stresses and others. As such, they are involved in the regulation of a wide spectrum of processes that modulate cell growth and cell death. These functions may be beneficial in cancer cells that escape growth regulation and exhibit unlimited proliferation. The effects of exogenous sphingolipids on cancer cells in vitro have been well documented; however, the effects of sphingolipids in vivo are less well understood. Since the mechanisms sphingolipids utilize in the prevention of cancer may be different from those in cancer treatment, modulation of cell growth versus induction of cell death, this review will focus on the known effects of orally administered sphingolipids in the prevention of colon cancer in different rodent models, and discuss the effect of sphingolipid metabolites on changes in cell proliferation and cell death that are important events in early carcinogenesis.

Citations

Oct 20, 2009·Lipids in Health and Disease·Lena OhlssonAke Nilsson
Mar 10, 2010·Journal of Lipid Research·Tatsuya SugawaraTakashi Hirata
Jun 2, 2010·Journal of Oleo Science·Tatsuya SugawaraTakashi Hirata
Jul 23, 2014·BioMed Research International·Isaac A RodriguezScott A Sell
Jun 25, 2014·BioMed Research International·Hui FanHui Li
Mar 9, 2012·Bioinorganic Chemistry and Applications·Michele IafiscoNorberto Roveri
Sep 15, 2006·FEBS Letters·Besim Ogretmen
Aug 6, 2015·Prostaglandins, Leukotrienes, and Essential Fatty Acids·P Castro-GómezJ Fontecha
Jun 23, 2012·Journal of Dairy Science·H KumuraK Kobayashi
Aug 3, 2016·Medicinal Research Reviews·Dominik Vogt, Holger Stark
Oct 28, 2005·Journal of Lipid Research·Ake Nilsson, Rui-Dong Duan
Nov 15, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ronan LordanIoannis Zabetakis
May 17, 2006·Journal of Dairy Science·R RombautK Dewettinck
Mar 21, 2007·Journal of Dairy Science·R RombautK Dewettinck
Oct 8, 2008·Molecular Nutrition & Food Research·Kirk W SimonEva M Schmelz
Dec 29, 2005·The Journal of Biological Chemistry·Mari KonoRichard L Proia
Nov 1, 2012·Food & Function·Christopher Beermann, Julia Hartung
Oct 17, 2012·Food & Function·Romina ZanabriaMilena Corredig
Apr 4, 2017·Journal of Nutritional Science and Vitaminology·Aoi FujiiTatsuya Sugawara
Oct 14, 2017·Bioscience Reports·Luis M Rodríguez-AlcaláJavier Fontecha
Oct 18, 2019·Journal of Nutritional Science and Vitaminology·Tatsuya SugawaraTakashi Hirata
Jun 1, 2007·Journal of Combinatorial Chemistry·Pedro SerranoAntonio Delgado

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