Sphingomyelin breakdown in T cells: role in activation, effector functions and immunoregulation

Biological Chemistry
Niklas Beyersdorf, Nora Müller

Abstract

Host T cell activation, a key step in obtaining adaptive immunity against pathogens, is initiated by the binding of the T cell receptor to a foreign antigenic peptide presented by the major histocompatibility complex on the surface of an antigen-presenting cell and, consequently, formation of an immunological synapse. Within the immunological synapse, the engagement of the T cell receptor in cooperation with simultaneous ligation of co-stimulatory molecules induces a precisely organized cascade of signaling events and pathways that regulate clonal expansion and differentiation of naïve T cells into effector T cells contributing to pathogen clearance. The biochemical changes that underlie T cell activation and differentiation, however, not only involve proteins but also lipids. In particular, catabolic cleavage of sphingomyelin generating ceramide can substantially influence functional responses in cells of the immune system. Changes in sphingomyelin and ceramide content have been reported to directly impact on membrane physiology, thus modifying signal transmission and interfering with diverse aspects of T cell activity. In this review we will focus on sphingomyelin breakdown/ceramide generation in T cells with regard to their ...Continue Reading

References

Jun 1, 1995·The Journal of Experimental Medicine·L M BoucherM Krönke
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·A Lepple-WienhuesF Lang
Feb 1, 2000·Immunology Today·B Seddon, D Mason
Feb 3, 2000·Nature Cell Biology·A O Hueber
May 23, 2001·The Journal of Experimental Medicine·P WongA Y Rudensky
Nov 1, 2002·The Biochemical Journal·Wim J van BlitterswijkJannie Borst
Apr 5, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Erich Gulbins
Aug 23, 2003·Oncogene·Heike GrassméErich Gulbins
Sep 3, 2004·Nature Reviews. Immunology·Thomas R Malek, Allison L Bayer
Apr 9, 2005·Journal of Leukocyte Biology·Leigh D ChurchStephen P Young
Jul 7, 2005·Nature Reviews. Immunology·Peter FriedlMatthias Gunzer
Oct 6, 2005·The Journal of Cell Biology·Katharina GausThomas Harder
Oct 18, 2005·Biochimica Et Biophysica Acta·Claudia R BollingerErich Gulbins
Nov 19, 2005·The Journal of Clinical Investigation·Shiqian ShenJuan J Lafaille
Mar 9, 2007·Journal of Virology·Catherine M FinneganRobert Blumenthal
Jan 25, 2008·Nature Reviews. Molecular Cell Biology·Yusuf A Hannun, Lina M Obeid
Feb 29, 2008·Annual Review of Immunology·Janis K BurkhardtMeredith H Shaffer
Mar 1, 2008·Science·Katarina TrajkovicMikael Simons
Jul 5, 2008·Annual Review of Cell and Developmental Biology·Michael L Dustin
Sep 13, 2008·Biochimica Et Biophysica Acta·Yang ZhangErich Gulbins
Jan 13, 2010·Immunity·Stephen C Jameson, David Masopust
May 13, 2010·Science Signaling·Marco A PurbhooDaniel M Davis
Jun 15, 2010·Molecular Membrane Biology·Dylan M OwenMarek Cebecauer
Jun 17, 2010·Neuromolecular Medicine·Bill X WuYusuf A Hannun
Sep 17, 2010·Cold Spring Harbor Perspectives in Biology·Michael L DustinAndrey S Shaw
Oct 20, 2010·The Journal of Biological Chemistry·Cristiana PerrottaEmilio Clementi
Nov 3, 2010·Immunology·Timothy J Thauland, David C Parker
Nov 30, 2010·FEBS Letters·Takashi SaitoAkiko Hashimoto-Tane
Dec 24, 2010·Nature Reviews. Immunology·Lakshmi BalagopalanLawrence E Samelson
Sep 29, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Denise TischnerHolger M Reichardt
Dec 20, 2011·Nature Immunology·Gabriela Constantin, Carlo Laudanna
Jun 22, 2012·Frontiers in Immunology·Christian BeckerHelmut Jonuleit
Oct 16, 2012·European Journal of Immunology·Tea GogishviliThomas Hünig
Jan 3, 2013·Immunological Reviews·Eilon ShermanLawrence E Samelson
Mar 9, 2013·Nature Reviews. Immunology·Lieping Chen, Dallas B Flies
May 18, 2013·Biochimica Et Biophysica Acta·Sudha KumariMichael L Dustin
Jul 16, 2013·Biochimica Et Biophysica Acta·Mohamad AdadaLina M Obeid
Oct 15, 2013·Trends in Cell Biology·Noa Beatriz Martín-CófrecesFrancisco Sánchez-Madrid
Oct 18, 2013·Tissue Antigens·F LafouresseL Dupré
Feb 12, 2014·Progress in Lipid Research·Bruno M CastroLiana C Silva

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Citations

May 24, 2016·EBioMedicine·Richard D SembaMark J Manary
Jun 15, 2016·Scientific Reports·Richard D SembaMark J Manary
Apr 6, 2017·Angewandte Chemie·Anne BurgertMarkus Sauer
Jun 17, 2018·Biological Chemistry·Jürgen Schneider-Schaulies, Niklas Beyersdorf
Feb 10, 2017·Neurology. Neuroimmunology and Neuroinflammation·Pablo VillosladaAzucena Castro
Sep 20, 2019·Nature Reviews. Endocrinology·Jorma IlonenRiitta Veijola
Sep 18, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Claudia HollmannNiklas Beyersdorf
Jul 10, 2018·Scientific Reports·Kenneth P HoughJessy S Deshane
Aug 29, 2019·Frontiers in Cell and Developmental Biology·Elita AvotaSibylle Schneider-Schaulies
Feb 9, 2021·Frontiers in Medicine·Ralf A Claus, Markus H Graeler
Oct 17, 2021·Journal of Hematology & Oncology·Yiyin ZhangHui Lin

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