Sphingomyelin synthase 2 deficiency inhibits the induction of murine colitis-associated colon cancer

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Toshio OhnishiToshiro Okazaki

Abstract

Sphingomyelin synthase 2 (SMS2) is the synthetic enzyme of sphingomyelin (SM), which regulates membrane fluidity and microdomain structure. SMS2 plays a role in LPS-induced lung injury and inflammation; however, its role in inflammation-mediated tumorigenesis is unclear. We investigated the effect of SMS2 deficiency on dextran sodium sulfate (DSS)-induced murine colitis and found inhibition of DSS-induced inflammation in SMS2-deficient (SMS2-/-) mice. DSS treatment induced a significant increase in ceramide levels, with a decrease of SM levels in SMS2-/-colon tissue, and demonstrated attenuation of the elevation of both inflammation-related gene expression and proinflammatory cytokines and chemokines, leukocyte infiltration, and MAPK and signal transducer and activator of transcription 3 activation. After undergoing transplantation of wild-type bone marrow, SMS2-/-mice also exhibited inhibition of DSS-induced inflammation in the colon, which suggested that SMS2 deficiency in bone marrow-derived immune cells was not involved in the inhibition of colitis. Finally, in an azoxymethane/DSS-induced cancer model, SMS2 deficiency significantly decreased tumor incidence in the colon. Our results demonstrate that SMS2 deficiency inhibits...Continue Reading

References

Dec 22, 1995·The Journal of Biological Chemistry·M E VenableL M Obeid
Jul 20, 2002·Inflammatory Bowel Diseases·Urban SjöqvistRobert Löfberg
Jun 21, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Tiruneh K HailemariamXian-Cheng Jiang
Jul 9, 2008·World Journal of Gastroenterology : WJG·Peter-Laszlo Lakatos, Laszlo Lakatos
Sep 26, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ashley J SniderLina M Obeid
Oct 1, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Toshihiko KawamoriLina M Obeid
Feb 3, 2009·Cancer Cell·Jacqueline Bromberg, Timothy C Wang
May 13, 2009·Nature Reviews. Genetics·Albert Tenesa, Malcolm G Dunlop
Jul 11, 2009·Circulation Research·Jing LiuXian-Cheng Jiang
Apr 28, 2010·Gastroenterology·Janos TerzićMichael Karin
Dec 31, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Satish GowdaRaj Wadgaonkar
Jun 15, 2011·The Journal of Biological Chemistry·Susumu MitsutakeYasuyuki Igarashi
Aug 23, 2011·The Journal of Biological Chemistry·Abo Bakr Abdel ShakorToshiro Okazaki
Oct 19, 2011·Cancer Metastasis Reviews·Hideki FuruyaToshihiko Kawamori
Jun 27, 2012·Proceedings of the National Academy of Sciences of the United States of America·Ana RiscoAna Cuenda
Nov 20, 2012·Seminars in Immunopathology·Sergei I Grivennikov
Dec 12, 2012·Journal of Clinical Immunology·Juliana Candido, Thorsten Hagemann
Dec 20, 2012·The Journal of Biological Chemistry·Joel D SchillingJean E Schaffer
Sep 26, 2013·Biochimica Et Biophysica Acta·Mónica García-BarrosYusuf A Hannun
Jun 6, 2014·Nature·Michael Maceyka, Sarah Spiegel
Sep 19, 2014·The Journal of Biological Chemistry·Yasuhiro HayashiAtsushi Yamashita
Oct 28, 2014·The Journal of Clinical Investigation·Emilie DegagnéJulie D Saba
Nov 9, 2014·Molecular Cancer Therapeutics·Ying ChenRui-Dong Duan
Feb 24, 2015·Apoptosis : an International Journal on Programmed Cell Death·Sehamuddin GaladariFaisal Thayyullathil
Jun 23, 2015·Cell Reports·Leonhard X HeinzGiulio Superti-Furga
Mar 12, 2016·Oncotarget·Guifang YanYongsheng Li

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Citations

Nov 17, 2017·Nutrients·Gregory H Norris, Christopher N Blesso
May 2, 2018·Biological & Pharmaceutical Bulletin·Satomi SuzukiToshihiko Murayama
Jan 24, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Makoto TaniguchiToshiro Okazaki
Mar 16, 2019·Frontiers in Pharmacology·Evanna HuynhJulang Li
Jul 22, 2018·Scientific Reports·B RusconiP I Tarr
Sep 11, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hadya Virupaksha DeepakKenji Monde
Nov 5, 2019·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Kamila PrymasKatarzyna Kwiatkowska
Oct 8, 2020·Journal of Lipid and Atherosclerosis·Makoto Taniguchi, Toshiro Okazaki
Jul 3, 2021·International Journal of Molecular Sciences·Shinji YamashitaTeruo Miyazawa
Aug 22, 2021·Cellular Signalling·Makoto Taniguchi, Toshiro Okazaki

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