Sphingosine 1-phosphate, a potential target in neovascular retinal disease.

The British Journal of Ophthalmology
Rasha A AlshaikhChristian Waeber

Abstract

Neovascular ocular diseases (such as age-related macular degeneration, diabetic retinopathy and retinal vein occlusion) are characterised by common pathological processes that contribute to disease progression. These include angiogenesis, oedema, inflammation, cell death and fibrosis. Currently available therapies target the effects of vascular endothelial growth factor (VEGF), the main mediator of pathological angiogenesis. Unfortunately, VEGF blockers are expensive biological therapeutics that necessitate frequent intravitreal administration and are associated with multiple adverse effects. Thus, alternative treatment options associated with fewer side effects are required for disease management. This review introduces sphingosine 1-phosphate (S1P) as a potential pharmacological target for the treatment of neovascular ocular pathologies. S1P is a sphingolipid mediator that controls cellular growth, differentiation, survival and death. S1P actions are mediated by five G protein-coupled receptors (S1P1-5 receptors) which are abundantly expressed in all retinal and subretinal structures. The action of S1P on S1P1 receptors can reduce angiogenesis, increase endothelium integrity, reduce photoreceptor apoptosis and protect the ret...Continue Reading

References

Oct 15, 1976·Documenta Ophthalmologica. Advances in Ophthalmology·J G Cunha-Vaz
Feb 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·C Portera-CailliauR Adler
Jun 19, 2002·Biochimica Et Biophysica Acta·Michael J Kluk, Timothy Hla
May 3, 2003·Nature Reviews. Molecular Cell Biology·Sarah Spiegel, Sheldon Milstien
Sep 10, 2003·Proceedings of the National Academy of Sciences of the United States of America·Junsuke IgarashiThomas Michel
Mar 17, 2004·American Journal of Respiratory and Critical Care Medicine·Xinqi PengJoe G N Garcia
May 13, 2004·The Journal of Biological Chemistry·Mari KonoRichard L Proia
Aug 4, 2004·The Journal of Cell Biology·Rachelle E TomanSarah Spiegel
Oct 16, 2004·The Journal of Biological Chemistry·Masayoshi YamanakaMaria Trojanowska
Nov 10, 2004·Eye·N N OsborneJ Melena
Nov 24, 2004·Progress in Retinal and Eye Research·Clyde Guidry
Aug 25, 2005·The Journal of Biological Chemistry·Michael MaceykaSarah Spiegel
Oct 27, 2005·Investigative Ophthalmology & Visual Science·Annal D MelethEmily Y Chew
Nov 30, 2005·Molecular and Cellular Biology·Kiyomi MizugishiRichard L Proia
Feb 28, 2006·Survey of Ophthalmology·Larry A DonosoGregory Hageman
Jun 8, 2006·Biochemical and Biophysical Research Communications·Isao InokiYoh Takuwa
Oct 27, 2006·Investigative Ophthalmology & Visual Science·Lynn W MainesCharles D Smith
Nov 15, 2006·Annals of Medicine·Karen M GehrsGregory S Hageman
Mar 3, 2007·The Journal of Clinical Investigation·Martin Friedlander
Apr 14, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Teresa SanchezTimothy Hla
Aug 22, 2007·The Journal of Clinical Investigation·Athanasia SkouraTimothy Hla
Jul 26, 2008·Progress in Retinal and Eye Research·J S PennM E Hartnett
Aug 9, 2008·Experimental Eye Research·James S SwaneyGlenn L Stoller
Sep 11, 2008·Journal of Cellular Physiology·Bing XiePeter A Campochiaro
Oct 15, 2008·Archives of Ophthalmology·Ben J E RaveneyAndrew D Dick
Oct 16, 2008·Journal of Neuroscience Research·Carolina E AbrahanNora P Rotstein
Nov 18, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Jen-Fu LeeMenq-Jer Lee
Apr 10, 2009·Investigative Ophthalmology & Visual Science·Gisela E MirandaNora P Rotstein
Oct 3, 2009·Investigative Ophthalmology & Visual Science·Carolina E AbrahanNora P Rotstein
Dec 10, 2009·PloS One·Takeru YoshimuraTatsuro Ishibashi
Dec 19, 2009·Investigative Ophthalmology & Visual Science·Alessandra Gonçalves CommodaroValquiria Bueno
Jan 22, 2010·Journal of Genetics·Yureeda QaziBalamurali K Ambati
Jan 26, 2010·The Journal of Biological Chemistry·Anke PennoThorsten Hornemann
Oct 6, 2010·Advances in Experimental Medicine and Biology·Christopher R GaultYusuf A Hannun

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Nature Reviews. Cancer
Nigel J Pyne, Susan Pyne
Development
Karen MendelsonTimothy Hla
Seminars in Immunopathology
Hideru Obinata, Timothy Hla
© 2021 Meta ULC. All rights reserved