Abstract
Ceramide, a sphingolipid generated by the hydrolysis of membrane-associated sphingomyelin, appears to play a role as a gauge of apoptosis. A further metabolite of ceramide, sphingosine 1-phosphate (SPP), prevents ceramide-mediated apoptosis, and it has been suggested that the balance between intracellular ceramide and SPP levels may determine the cell fate (Cuvillier, O., Pirianov, G, Kleuser, B., Vanek, P. G., Coso, O. A., Gutkind, J. S., and Spiegel, S. (1996) Nature 381, 800-803). Here, we investigated the role of SPP and the protein kinase C activator, phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), in the caspase cascade leading to the proteolysis of poly(ADP-ribose) polymerase (PARP) and lamins. In Jurkat T cells, Fas ligation or addition of exogenous C2-ceramide induced activations of caspase-3/CPP32 and caspase-7/Mch3 followed by PARP cleavage, effects that can be blocked either by SPP or TPA. Furthermore, both SPP and TPA inhibit the activation of caspase-6/Mch2 and subsequent lamin B cleavage. Ceramide, in contrast to Fas ligation, did not induce activation of caspase-8/FLICE and neither SPP nor TPA were able to prevent this activation. Thus, SPP, likely generated via protein kinase C-mediated activation of ...Continue Reading
References
May 15, 1992·Cell·C A RayD J Pickup
Oct 1, 1994·The Journal of Experimental Medicine·M G CifoneR Testi
May 4, 1995·Nature·M EnariS Nagata
May 4, 1995·Nature·M LosK Schulze-Osthoff
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·Y A LazebnikW C Earnshaw
Jul 6, 1995·Nature·D W NicholsonY A Lazebnik
May 19, 1995·Cell·H HsuD V Goeddel
Jun 2, 1995·Cell·M TewariV M Dixit
Aug 1, 1994·The Journal of Experimental Medicine·A Haimovitz-FriedmanR N Kolesnick
Nov 19, 1993·Cell·J YuanH R Horvitz
Jan 14, 1994·Biochemical and Biophysical Research Communications·N MazurekY Igarashi
Mar 19, 1993·Science·L M ObeidY A Hannun
Jan 26, 1996·The Journal of Biological Chemistry·J SchlegelD W Nicholson
Jan 19, 1996·The Journal of Biological Chemistry·H DuanV M Dixit
Mar 7, 1996·Nature·M VerheijR N Kolesnick
Mar 1, 1996·The Journal of Biological Chemistry·A M ChinnaiyanV M Dixit
Mar 1, 1996·The Journal of Biological Chemistry·A M ChinnaiyanV M Dixit
Apr 1, 1996·Journal of Neurochemistry·D A Wiesner, G Dawson
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·D L Vaux, A Strasser
May 28, 1996·Proceedings of the National Academy of Sciences of the United States of America·J ZhangY A Hannun
May 15, 1996·The Biochemical Journal·M J SmythL M Obeid
Jun 27, 1996·Nature·O CuvillierS Spiegel
Jul 12, 1996·The Journal of Biological Chemistry·K OrthV M Dixit
Jun 14, 1996·Cell·M MuzioV M Dixit
Jul 29, 1996·FEBS Letters·E L GreidingerA Rosen
Aug 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·A TakahashiW C Earnshaw
Apr 1, 1996·Current Opinion in Cell Biology·S SpiegelR Kolesnick
Oct 21, 1996·FEBS Letters·N MizushimaN Miyasaka
Oct 25, 1996·The Journal of Biological Chemistry·S M SrinivasulaE S Alnemri
Dec 13, 1996·Science·Y A Hannun
Dec 13, 1996·The Journal of Biological Chemistry·Y R ChenT H Tan
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·S M SrinivasulaE S Alnemri
Jan 1, 1997·Molecular and Cellular Biology·P JuoJ Blenis
Feb 3, 1997·The Journal of Experimental Medicine·G S DbaiboY A Hannun
Mar 21, 1997·The Journal of Biological Chemistry·Q ZhouG S Salvesen
Jun 27, 1997·Cell·X YangD Baltimore
Aug 1, 1997·Trends in Biochemical Sciences·D W Nicholson, N A Thornberry
Sep 26, 1997·The Journal of Biological Chemistry·A D TepperW J van Blitterswijk
Citations
Jul 8, 1999·Journal of Cellular Physiology·S G PayneL J Guilbert
Mar 29, 2001·International Journal of Cancer. Journal International Du Cancer·T KurokawaA Mackensen
Feb 19, 2000·Biochemical and Biophysical Research Communications·Y YamazakiH Ohta
Oct 18, 2000·Biochemical and Biophysical Research Communications·I K KimY K Jung
Oct 17, 2003·Archives of Pharmacal Research·Dong-Seok KimKyoung-Chan Park
Oct 30, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Marie-Laure RantyJean-Claude Quintyn
Oct 18, 2011·Cancer Metastasis Reviews·Jessie W YesterTomasz Kordula
Dec 31, 2003·Bioorganic & Medicinal Chemistry·Hayato NiiroKenji Ogino
Mar 17, 2004·Experimental Cell Research·Nicholas J Donato, Jim Klostergaard
Dec 5, 1998·Biochimica Et Biophysica Acta·D K Perry, Y A Hannun
Apr 28, 2001·Prostaglandins & Other Lipid Mediators·E J Goetzl
Apr 28, 2001·Prostaglandins & Other Lipid Mediators·A Olivera, S Spiegel
Nov 22, 2000·Leukemia Research·Y MasudaK Nakaya
Sep 15, 1998·Molecular Immunology·L ChenS Pillai
Jan 11, 2001·Pharmacology & Therapeutics·S Pyne, N Pyne
Nov 13, 2002·Biochimica Et Biophysica Acta·Ravi KothapalliThomas P Loughran
Nov 30, 2000·Immunology Today·E E Prieschl, T Baumruker
May 20, 2003·Biology of the Cell·Benjamin BernardChristiane Mougin
May 30, 2001·Molecular and Cellular Endocrinology·Y TakuwaS Sakurada
Jul 23, 2003·Cellular Signalling·Dong-Seok KimKyoung-Chan Park
Feb 19, 2000·Cellular Signalling·R T Dobrowsky
Oct 31, 1998·Current Opinion in Immunology·M E Peter, P H Krammer
Feb 1, 2000·Trends in Cell Biology·Y A Hannun, C Luberto
Jun 6, 2003·Bioorganic & Medicinal Chemistry·Keiji ShikataTaro Tachibana
Apr 5, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Timothy Hla
Apr 5, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Benedetta CinqueM Grazia Cifone
Apr 5, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Olivier Cuvillier, Thierry Levade
Jan 4, 2001·The International Journal of Biochemistry & Cell Biology·I SchmitzP H Krammer
Apr 13, 2000·Biochimica Et Biophysica Acta·S Spiegel, S Milstien
Jun 19, 2002·Biochimica Et Biophysica Acta·Hervé Le StunffSarah Spiegel
Jun 19, 2002·Biochimica Et Biophysica Acta·Yoh Takuwa
Jun 19, 2002·Biochimica Et Biophysica Acta·Wolfgang Siess
Jan 18, 2003·Biochimica Et Biophysica Acta·Jonathan L Tilly, Richard N Kolesnick
Jan 18, 2003·Biochimica Et Biophysica Acta·David K Perry
Jan 18, 2003·Biochimica Et Biophysica Acta·Olivier Cuvillier
Jan 18, 2003·Biochimica Et Biophysica Acta·Michael MaceykaSarah Spiegel
Apr 27, 1999·Biochimica Et Biophysica Acta·T Levade, J P Jaffrézou
Nov 11, 2005·Leukemia·E BonhoureO Cuvillier
Feb 5, 1999·The Biochemical Journal·W C HungL Y Chuang
Jul 6, 2000·The Biochemical Journal·S Pyne, N J Pyne
Mar 10, 2001·Journal of Neurochemistry·L C EdsallS Milstien
Jun 3, 1999·Proceedings of the Association of American Physicians·E J GoetzlJ S Kenney
Aug 3, 1999·The Journal of Experimental Medicine·E E PrieschlT Baumruker
Oct 17, 1998·The EMBO Journal·K MeerschaertJ Gettemans
Jul 7, 1999·Journal of the National Cancer Institute·B J MaurerC P Reynolds
Aug 20, 2004·Biology of Reproduction·Z Roth, P J Hansen
Mar 9, 1999·Alcoholism, Clinical and Experimental Research·A SlomianyB L Slomiany
Jun 18, 2002·Journal of Cellular and Molecular Medicine·S ClejanN Rosensweig
Jul 21, 2001·Molecular and Cellular Biology·S GalandeT Kohwi-Shigematsu
Oct 23, 2002·Molecular and Cellular Biology·Xiaodong ShuDaniel Broek