Sphingosine 1-phosphate levels in plasma and HDL are altered in coronary artery disease

Basic Research in Cardiology
Katherine SattlerBodo Levkau

Abstract

High-density lipoproteins (HDL) are the major plasma carriers for sphingosine 1-phosphate (S1P) in healthy individuals, but their S1P content is unknown for patients with coronary artery disease (CAD). The aim of the study was to determine whether the S1P levels in plasma and HDL are altered in coronary artery disease. S1P was determined in plasma and HDL isolated by ultracentrifugation from patients with myocardial infarction (MI, n = 83), stable CAD (sCAD, n = 95), and controls (n = 85). In our study, total plasma S1P levels were lower in sCAD than in controls (305 vs. 350 pmol/mL). However, normalization to HDL-cholesterol (a known determinant of plasma S1P) revealed higher normalized plasma S1P levels in sCAD than in controls (725 vs. 542 pmol/mg) and even higher ones in MI (902 pmol/mg). The S1P amount contained in isolated HDL from these individuals was lower in sCAD than in controls (S1P per protein in HDL: 132 vs. 153 pmol/mg). The amount of total plasma S1P bound to HDL was lower in sCAD and MI than in controls (sCAD: 204, MI: 222, controls: 335 pmol/mL), while the non-HDL-bound S1P was, accordingly, higher (sCAD: 84, MI: 81, controls: 10 pmol/mL). HDL-bound plasma S1P was dependent on the plasma HDL-C in all groups, b...Continue Reading

References

Jul 22, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·D S FreedmanJ A Walker
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·P XiaM A Vadas
Dec 16, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·B F AsztalosE J Schaefer
Jul 10, 2003·American Heart Journal·Douglas H DeutschmanRoger A Sabbadini
Jan 24, 2004·Zeitschrift für Kardiologie·C W Hamm, UNKNOWN Deutsche Gesellschaft fur Kardiologie- Herz- und Kreislaufforschung
Feb 18, 2004·The Journal of Clinical Investigation·Jerzy-Roch NoferBodo Levkau
Feb 21, 2004·European Journal of Pharmacology·Ken ShimamuraToshihiko Murayama
Aug 25, 2004·Proceedings of the National Academy of Sciences of the United States of America·Constanze BergtJay W Heinecke
Feb 18, 2005·Current Opinion in Clinical Nutrition and Metabolic Care·Arnold von EckardsteinLucia Rohrer
Sep 27, 2005·Lancet·K George M M AlbertiUNKNOWN IDF Epidemiology Task Force Consensus Group
Mar 3, 2007·The Journal of Clinical Investigation·Tomas VaisarJay W Heinecke
Sep 28, 2007·The New England Journal of Medicine·Philip BarterUNKNOWN Treating to New Targets Investigators
Jan 25, 2008·Nature Reviews. Molecular Cell Biology·Yusuf A Hannun, Lina M Obeid
Feb 24, 2009·Cardiovascular Research·Katherine Sattler, Bodo Levkau

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Citations

Mar 7, 2012·Cardiovascular Drugs and Therapy·Sarin J SomersSandrine Lecour
Jul 3, 2013·Cardiovascular Research·Monica GomaraschiLaura Calabresi
May 9, 2013·Current Opinion in Lipidology·Christina Christoffersen, Lars Bo Nielsen
May 9, 2013·Current Opinion in Lipidology·Emmanuel E EgomHandrean Soran
Dec 5, 2012·Journal of Lipids·Samar M HammadRichard L Klein
Jun 4, 2014·Cardiovascular Research·Francesco PotìJerzy-Roch Nofer
Apr 23, 2015·Molecular Medicine Reports·Li-Zhu HuangYao Zhang
May 12, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xiao-Dong JingQiang She
Jan 21, 2016·Basic Research in Cardiology·M R ReforgiatoPaola Signorelli
Jun 28, 2012·Biochimica Et Biophysica Acta·Joel S Karliner
Mar 15, 2016·Translational Research : the Journal of Laboratory and Clinical Medicine·Wijtske Annema, Arnold von Eckardstein
Feb 12, 2011·British Journal of Pharmacology·Mirjam SchuchardtMarkus van der Giet
Mar 16, 2013·British Journal of Pharmacology·A Tran-DinhO Meilhac
Mar 24, 2016·Current Atherosclerosis Reports·C RosalesH J Pownall
Sep 26, 2015·Journal of the American College of Cardiology·Juan J Badimon, Carlos G Santos-Gallego
Jul 28, 2013·Critical Reviews in Clinical Laboratory Sciences·Emmanuel E EgomMamas A Mamas
Apr 21, 2016·Cellular Signalling·Alessandra CastaldiNicole H Purcell
Jul 11, 2014·Biochimica Et Biophysica Acta·Brent A Wilkerson, Kelley M Argraves
Oct 19, 2012·Atherosclerosis·Thorsten Hornemann, Tilla S Worgall
Apr 27, 2016·Current Atherosclerosis Reports·Teresa Sanchez
Jan 1, 2015·Current Opinion in Lipidology·Anna BorupChristina Christoffersen
May 7, 2016·Chemistry and Physics of Lipids·C Roger WhiteG M Anantharamaiah

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