Sphingosine-1-phosphate receptor 1 agonist SEW2871 prolongs heterotopic heart allograft survival in mice

International Immunopharmacology
Qian NiHui Yin

Abstract

Sphingosine-1-phosphate (S1P) is a biologically active metabolite of plasma-membrane sphingolipids that is essential for immune cell trafficking. Recent studies have revealed immunomodulatory functions of S1P and its receptors (S1PR1-S1PR5) in many inflammatory conditions, such as asthma and autoimmunity. Here, we explore the efficacy of SEW2871, a selective S1PR1 agonist, in the prevention of acute allograft rejection in a murine cardiac transplantation model. Treatment of recipient mice with SEW2871 significantly prolongs cardiac allograft survival as compared to those recipients treated with control vehicle. The enhanced graft survival is associated with reduced circulating lymphocytes and allograft inflammatory cell infiltration. The cytokine analysis showed decreased allograft expression of TNF-α, IFN-γ and IL-2 in the SEW2871-treated mice. Moreover, administration of SEW2871 increases the percentage of CD4(+) T regulatory cells and FoxP3 expression in spleen of allograft recipients. Therefore, SEW2871 plays a critical role in regulation of lymphocyte trafficking and development, which directly contributes to prolongation of the allograft survival.

References

Jan 28, 1994·Cell·W E Paul, R A Seder
May 6, 2006·Biochemical and Biophysical Research Communications·Takashi KanekoEiji Kobayashi
Mar 16, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·N SchaeferA Türler
Sep 13, 2008·Nature Reviews. Immunology·Juan RiveraAna Olivera
May 27, 2010·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Markus H Gräler
Jun 30, 2010·The Journal of Experimental Medicine·Shobha ThangadaTimothy Hla
Oct 28, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·T PechN Schaefer
Dec 17, 2010·Trends in Pharmacological Sciences·Hongbo Chi
Dec 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Ji Woong ChoiJerold Chun
Aug 28, 2012·Journal of Biochemistry·Yu HisanoAtsuo Kawahara
Apr 23, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S HirayamaS Keshavjee
Feb 11, 2014·Journal of Neuroimmunology·Douglas Kazutoshi SatoMasashi Aoki
Mar 7, 2014·Immunology·Christopher S GarrisMay H Han
Mar 13, 2014·Vascular Cell·Xinguo JiangMark R Nicolls
Aug 5, 2014·Clinical Immunology : the Official Journal of the Clinical Immunology Society·O MillánM Brunet
Oct 29, 2014·Nature Reviews. Nephrology·Anita S Chong, David L Perkins

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