Sphingosine-1-phosphate receptor subtype 2 signaling in endothelial senescence-associated functional impairments and inflammation

Current Atherosclerosis Reports
Jiawei ZhaoMenq-Jer Lee

Abstract

Endothelial inflammation is an important risk factor in the initiation and development of vascular disease. Therefore, signaling cascades and patho-physiological outcomes of endothelial inflammation are important questions in vascular biology. Recent studies suggest that sphingosine-1-phosphate receptor subtype 2 (S1PR2) signaling in endothelial cells (ECs) play a critical role in endothelial inflammation. For example, ECs present in atherosclerotic plaques exhibit senescence phenotype. Levels of S1PR2 are markedly increased in cultured senescent ECs and in lesion regions of atherosclerotic endothelium. Also, inflammatory cytokines and mechanical flow stress profoundly increase S1PR2 levels in ECs. Inhibition of endothelial S1PR2 signaling diminishes endothelial senescence-associated functional impairments and atherogenic stimuli-induced endothelial activation. In contrast, activation of endothelial S1PR2 stimulates the production of pro-inflammatory chemokines/cytokines and lipid mediators in ECs. In this article, we will review signaling and functions of sphingosine-1-phosphate (S1P) receptors in endothelial biology, with particular focus on endothelial S1PR2 signaling-mediated endothelial inflammation.

References

Apr 18, 1998·The Biochemical Journal·G C ZondagW H Moolenaar
Apr 7, 1998·Molecular and Cellular Biology·C A CantwellP F Johnson
Mar 18, 1999·Journal of Leukocyte Biology·S Spiegel
Dec 2, 1999·Experimental Cell Research·W H Moolenaar
Jul 6, 2000·FEBS Letters·S Spiegel, S Milstien
Feb 7, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E VasileH F Dvorak
Aug 16, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·A B FisherR M Nerem
Nov 16, 2001·Biochemical Society Transactions·S C LinnA H Merrill
May 31, 2002·Pharmacological Reviews·Jerold ChunGabor Tigyi
Jun 5, 2003·Biochimica Et Biophysica Acta·Kentaro Hanada
Feb 12, 2004·Journal of Molecular and Cellular Cardiology·Tohru MinaminoIssei Komuro
Jul 27, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Wouter H MoolenaarBen N G Giepmans
Aug 9, 2005·Journal of Biomechanics·Yi-Shuan J LiShu Chien
Apr 14, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Teresa SanchezTimothy Hla
Jan 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mehmet A EskanDenis F Kinane
Feb 22, 2008·Nature·Daniel J Rader, Alan Daugherty
Nov 18, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Jen-Fu LeeMenq-Jer Lee
Oct 16, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Athanasia SkouraTimothy Hla
Jan 21, 2011·The Cochrane Database of Systematic Reviews·Fiona TaylorShah Ebrahim
Feb 24, 2011·Expert Opinion on Drug Safety·Thura T Abd, Terry A Jacobson
May 4, 2011·World Journal of Biological Chemistry·Binks W Wattenberg
May 11, 2011·The Journal of Clinical Investigation·Myat Lin OoTimothy Hla
May 23, 2012·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·James R Van Brocklyn, Joseph B Williams

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Citations

Jan 26, 2016·American Journal of Human Genetics·Regie Lyn P Santos-CortezSuzanne M Leal
Dec 26, 2015·Progress in Lipid Research·Antonio Gomez-MuñozMarta Ordoñez
Nov 26, 2015·Mediators of Inflammation·Shailaja Mahajan-ThakurBernhard H Rauch
May 29, 2019·Pediatric Blood & Cancer·Miriam B G MorrellKeri L Schadler
Sep 12, 2020·Neuromolecular Medicine·Bhakta Prasad Gaire, Ji Woong Choi
Aug 16, 2018·The Journal of Clinical Investigation·Magali TrayssacLina M Obeid
Jul 3, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xia WangNana Yang
Dec 12, 2020·International Journal of Sports Medicine·Mário EstevesJose Alberto Duarte
Aug 4, 2021·International Journal of Sports Medicine·Mário EstevesJose Alberto Duarte

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