Sphingosine-1-phosphate (S1P) receptors: Promising drug targets for treating bone-related diseases.

Journal of Cellular and Molecular Medicine
Lincheng ZhangYueqi Chen

Abstract

Sphingosine-1-phosphate (S1P) is a natural bioactive lipid molecule and a common first or second messenger in the cardiovascular and immune systems. By binding with its receptors, S1P can serve as mediator of signalling during cell migration, differentiation, proliferation and apoptosis. Although the predominant role of S1P in bone regeneration has been noted in many studies, this role is not as well-known as its roles in the cardiovascular and immune systems. In this review, we summarize previous research on the role of S1P receptors (S1PRs) in osteoblasts and osteoclasts. In addition, S1P is regarded as a bridge between bone resorption and formation, which brings hope to patients with bone-related diseases. Finally, we discuss S1P and its receptors as therapeutic targets for treating osteoporosis, inflammatory osteolysis and bone metastasis based on the biological effects of S1P in osteoclastic/osteoblastic cells, immune cells and tumour cells.

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Citations

Jan 15, 2021·European Journal of Medicinal Chemistry·Molly CongdonWebster L Santos
Feb 18, 2021·Journal of Cellular and Molecular Medicine·Xuewen WangHongwei Lu
Jul 9, 2021·Journal of Inflammation Research·Eileen MoritzBirte Holtfreter
Jul 31, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Alexander Kalinkovich, Gregory Livshits

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