Sphingosine 1-phosphate signaling in bone remodeling: multifaceted roles and therapeutic potential

Expert Opinion on Therapeutic Targets
Anastasia MeshcheryakovaPeter Pietschmann

Abstract

Sphingolipids belong to a complex class of lipid molecules that are crucially involved in the regulation of important biological processes including proliferation, migration and apoptosis. Given the significant progress made in understanding the sphingolipid pathobiology of several diseases, sphingolipid-related checkpoints emerge as attractive targets. Recent data indicate the multifaceted contribution of the sphingolipid machinery to osteoclast - osteoblast crosstalk, representing one of the pivotal interactions underlying bone homeostasis. Imbalances in the interplay of osteoblasts and osteoclasts might lead to bone-related diseases such as osteoporosis, rheumatoid arthritis, and bone metastases. Areas covered: We summarize and analyze the progress made in bone research in the context of the current knowledge of sphingolipid-related mechanisms regulating bone remodeling. Particular emphasis was given to bioactive sphingosine 1-phosphate (S1P) and S1P receptors (S1PRs). Moreover, the mechanisms of how dysregulations of this machinery cause bone diseases, are covered. Expert opinion: In the context of bone diseases, pharmacological interference with sphingolipid machinery may lead to novel directions in therapeutic strategies....Continue Reading

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Citations

Oct 9, 2019·Cells·Chun Wang, Gabriel Mbalaviele
Aug 3, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Alaeddine El JamalCarole Bougault
Feb 14, 2020·Expert Opinion on Therapeutic Targets·Luigi GennariIacopo Chiodini
Mar 11, 2020·Journal of Cellular and Molecular Medicine·Lincheng ZhangYueqi Chen
Dec 6, 2018·Cellular and Molecular Life Sciences : CMLS·Beom-Jun Kim, Jung-Min Koh
Jun 10, 2019·Clinical Hemorheology and Microcirculation·Rebecca RotheJens Pietzsch
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Oct 28, 2020·Journal of Cellular Biochemistry·Yuki NagataNoriyoshi Kurihara
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May 27, 2021·Current Pharmaceutical Design·Wheeler TorresValmore Bermudez

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Methods Mentioned

BETA
antisense oligodeoxynucleotides

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