Sphingosine kinase: a key to solving the 'French Paradox'?

British Journal of Pharmacology
Jeremy A Hengst, Jong K Yun

Abstract

A host of beneficial effects have been attributed to the red wine polyphenol, resveratrol. Foremost, among these are its anti-cancer properties. Yet, the mechanism by which resveratrol achieves these effects are unknown. In this issue of the BJP, Lim et al. report that resveratrol and its higher order oligomers inhibit sphingosine kinase 1 (SphK1). SphK1 is a key regulator of sphingolipid metabolism and alterations of this key metabolic pathway have been linked to many hyperproliferative diseases. This study identifies a target for the action of resveratrol and its higher order oligomers and opens the door to evaluation of SphK1 as a target for chemo-prevention of cancer.

References

Nov 7, 2006·Nature·Joseph A BaurDavid A Sinclair
Apr 26, 2011·Trends in Molecular Medicine·Susan Pyne, Nigel J Pyne
Jun 29, 2011·Anti-cancer Agents in Medicinal Chemistry·Kenneth C LohJulie D Saba
Sep 24, 2011·Cancer Research·Susan PyneNigel J Pyne
Jan 11, 2012·The International Journal of Biochemistry & Cell Biology·Daniela HartmannSabine Grösch

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Citations

Feb 22, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Iva FernandesVictor de Freitas
May 23, 2013·Bulletin du cancer·François EisingerOlivier Cussenot
Sep 21, 2019·European Journal of Medicinal Chemistry·Giada CatalognaNicola Perrotti

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