Sphingosine kinases and sphingosine-1-phosphate are critical for transforming growth factor beta-induced extracellular signal-regulated kinase 1 and 2 activation and promotion of migration and invasion of esophageal cancer cells.

Molecular and Cellular Biology
Anna V MillerDeborah A Lebman

Abstract

Transforming growth factor beta (TGFbeta) plays a dual role in oncogenesis, acting as both a tumor suppressor and a tumor promoter. These disparate processes of suppression and promotion are mediated primarily by Smad and non-Smad signaling, respectively. A central issue in understanding the role of TGFbeta in the progression of epithelial cancers is the elucidation of the mechanisms underlying activation of non-Smad signaling cascades. Because the potent lipid mediator sphingosine-1-phosphate (S1P) has been shown to transactivate the TGFbeta receptor and activate Smad3, we examined its role in TGFbeta activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) and promotion of migration and invasion of esophageal cancer cells. Both S1P and TGFbeta activate ERK1/2, but only TGFbeta activates Smad3. Both ligands promoted ERK1/2-dependent migration and invasion. Furthermore, TGFbeta rapidly increased S1P, which was required for TGFbeta-induced ERK1/2 activation, as well as migration and invasion, since downregulation of sphingosine kinases, the enzymes that produce S1P, inhibited these responses. Finally, our data demonstrate that TGFbeta activation of ERK1/2, as well as induction of migration and invasion, is mediated ...Continue Reading

References

Mar 31, 1995·The Journal of Biological Chemistry·M T Hartsough, K M Mulder
Jul 25, 1998·Genes & Development·Y G ChenJ Massagué
Jul 16, 1999·Analytical Biochemistry·L C Edsall, S Spiegel
Sep 7, 2000·Journal of the National Cancer Institute·M P de CaesteckerA B Roberts
Oct 29, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D EnglishJ G Garcia
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·J ZavadilE P Bottinger
Oct 31, 2001·Trends in Cell Biology·R J Akhurst, R Derynck
Nov 26, 2002·Biochemical and Biophysical Research Communications·Makoto OsadaYukio Ozaki
May 3, 2003·Nature Reviews. Molecular Cell Biology·Sarah Spiegel, Sheldon Milstien
Jul 16, 2003·Proceedings of the National Academy of Sciences of the United States of America·Anita B Roberts, Lalage M Wakefield
Oct 9, 2003·The EMBO Journal·Stuart M PitsonBinks W Wattenberg
Jul 13, 2004·The Journal of Biological Chemistry·Bettina SauerBurkhard Kleuser
Oct 16, 2004·The Journal of Biological Chemistry·Masayoshi YamanakaMaria Trojanowska
Nov 19, 2004·Neoplasia : an International Journal for Oncology Research·Lu XieHarold L Moses
Dec 14, 2004·The Journal of Biological Chemistry·Michael D DavisKevin R Lynch
Feb 25, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Heinfried H RadekeBurkhard Kleuser
May 5, 2005·Molecular and Cellular Biology·Sravan K GoparajuSarah Spiegel
Jun 14, 2005·The Journal of Biological Chemistry·Nitai C HaitSarah Spiegel
Sep 26, 2006·Biochimica Et Biophysica Acta·Nitai C HaitSarah Spiegel
Dec 23, 2006·Seminars in Radiation Oncology·Rebecca S Holmes, Thomas L Vaughan
Dec 23, 2006·Seminars in Radiation Oncology·J Rüdiger Siewert, Katja Ott
Jan 4, 2007·The American Journal of Pathology·Christina D KellerBurkhard Kleuser
Feb 22, 2007·The Journal of Biological Chemistry·Nitai C HaitSarah Spiegel
Jun 27, 2007·Molecular and Cellular Biology·Laurence LevyCaroline S Hill
Jul 21, 2007·American Journal of Respiratory Cell and Molecular Biology·Yuko KonoMitsuhiro Yokoyama

❮ Previous
Next ❯

Citations

Oct 30, 2008·Current Opinion in Lipidology·Jannick Pétremand, Christian Widmann
Jan 13, 2012·Pigment Cell & Melanoma Research·SubbaRao V MadhunapantulaGavin P Robertson
Jul 8, 2010·Cells, Tissues, Organs·María M FacchinettiAlejandro C Curino
May 4, 2011·World Journal of Biological Chemistry·James R Van Brocklyn
Aug 7, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qiushi WangSongbin Fu
Jun 28, 2014·Biomolecules·Anthony S DonTimothy A Couttas
Mar 26, 2010·Expert Opinion on Therapeutic Targets·Thomas H BeckhamXiang Liu
Jan 7, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Lan ZhangYanmei Ma
Sep 10, 2014·Cancer Cell International·Paulette M TamashiroToshihiko Kawamori
Dec 3, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Wei LiuLi Cai
May 9, 2015·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Anna LaurenzanaChiara Donati
Aug 1, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Erlin SunRuifa Han
Nov 6, 2010·Cytokine & Growth Factor Reviews·Pu Xia, Carol Wadham
Nov 2, 2016·Frontiers in Oncology·Yamila I RodriguezSergio E Alvarez
Sep 28, 2010·Trends in Biochemical Sciences·Stuart M Pitson
Nov 6, 2008·Cellular Signalling·Chiara DonatiPaola Bruni
Feb 11, 2012·International Journal of Cancer. Journal International Du Cancer·Thomas H BeckhamXiang Liu
Oct 25, 2014·Nature Reviews. Cancer·Hua YuRichard Jove
May 4, 2013·The FEBS Journal·Heidi A Neubauer, Stuart M Pitson
Aug 6, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Francesca CencettiPaola Bruni
Feb 13, 2020·Mini Reviews in Medicinal Chemistry·Ankur VaidyaSanjay Kumar Jain
Jan 1, 2013·Biomolecules·Paulette M TamashiroToshihiko Kawamori
Aug 30, 2020·Cells·Lorry CarriéNathalie Andrieu-Abadie
May 26, 2018·International Journal of Molecular Sciences·Hendrik UngefrorenBernhard H Rauch
Jun 28, 2014·Molecular Medicine Reports·Jiazhen ShiZhihua Kang
Oct 31, 2020·Cancers·Laurence PellerinNathalie Andrieu-Abadie

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.