Sphingosine rescues aged mice from pulmonary pseudomonas infection

The Journal of Surgical Research
Teresa C RiceCharles C Caldwell

Abstract

Bacterial lung infection is a leading cause of death for those 65 y or older, often requiring intensive care unit admission and mechanical ventilation, which consumes considerable health care resources. Although administration of antibiotics is the standard of care for bacterial pneumonia, its overuse has led to the emergence of multidrug resistant organisms. Therefore, alternative strategies to help minimize the effects of bacterial pneumonia in the elderly are necessary. As studies have shown that sphingosine (SPH) has inherent bacterial killing properties, our goal was to assess whether it could act as a prophylactic treatment to protect aged mice from pulmonary infection by Pseudomonas aeruginosa. Aged (51 wk) and young (8 wk) C57Bl/6 mice were used in this study. Pulmonary SPH levels were determined by histology. SPH content of microparticles was quantified using a SPH kinase assay. Pneumonia was induced by intranasally treating mice with 106 Colony Forming Unit (CFU) P aeruginosa. Microparticles were isolated from young mice, whereas some were further incubated with SPH. We observed that SPH levels are reduced in the bronchial epithelial cells as well as the bronchoalveolar lavage microparticles isolated from aged mice, w...Continue Reading

Citations

Oct 3, 2018·Surgical Infections·Jennifer E BakerMichael J Edwards
Oct 16, 2019·Journal of Drug Targeting·Qianyu ZhangXuefeng Xia
Dec 22, 2019·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Sascha BeckKatrin Anne Becker
Jun 3, 2021·Cells·Yuqing WuHeike Grassmé
May 23, 2021·Advanced Drug Delivery Reviews·Anna Lena JungBirke J Benedikter
Sep 22, 2021·Scientific Reports·Henning CarstensMarkus Kamler

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