Sphingosylphosphorylcholine-induced ERK activation inhibits melanin synthesis in human melanocytes

Pigment Cell Research
D S KimKyoung-Chan Park

Abstract

Sphingosylphosphorylcholine (SPC) is emerging as a potent signaling-lipid mediator. In this study, we investigated the effects of SPC on melanogenesis using cultured human melanocytes. Our results show that SPC significantly inhibits melanin synthesis in a concentration-dependent manner, and further that it reduces the activity of tyrosinase, the rate-limiting melanogenic enzyme. SPC treatment was also found to induce short-thick dendrites in human melanocytes, but not to reduce tyrosinase activity in a cell-free system, whereas kojic acid directly inhibited tyrosinase. These results suggest that SPC reduces pigmentation by indirectly regulating tyrosinase. In further experiments, SPC was found to downregulate microphthalmia-associated transcription factor (MITF) and tyrosinase, and Western blotting showed that SPC induces the activations of extracellular signal-regulated kinase (ERK) and 90 kDa ribosomal S6 kinase (RSK-1). Moreover, the specific ERK pathway inhibitor, PD98059, blocked the hypopigmentation effect of SPC, and abrogated the SPC-mediated downregulation of MITF. These results suggest that the ERK pathway is involved in the melanogenic signaling cascade, and that ERK activation by SPC reduces melanin synthesis via M...Continue Reading

References

Nov 27, 1991·Biochemical and Biophysical Research Communications·N N Desai, S Spiegel
Mar 1, 1989·Pigment Cell Research·V J Hearing, M Jiménez
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M Eisinger, O Marko
Jan 1, 1994·Skin Pharmacology : the Official Journal of the Skin Pharmacology Society·T P DooleyL M Thomasco
Feb 1, 1996·The Journal of Investigative Dermatology·L SunT B Nielsen
May 23, 1998·The Journal of Biological Chemistry·W EnglaroR Ballotti
Aug 12, 1998·The Journal of Cell Biology·C BertolottoR Ballotti
Feb 19, 2000·Cellular Signalling·R T Dobrowsky
Jun 7, 2000·Pigment Cell Research·R Buscà, R Ballotti
Aug 22, 2000·Pigment Cell Research·M Tachibana
Oct 6, 2000·Journal of Voice : Official Journal of the Voice Foundation·W S BrownC M Sapienza
Feb 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Han-Mo KooGeorge F Vande Woude
May 30, 2002·Cellular Signalling·Dong-Seok KimKyoung-Chan Park
May 3, 2003·Nature Reviews. Molecular Cell Biology·Sarah Spiegel, Sheldon Milstien
Nov 25, 2003·Pigment Cell Research·Kazuhiko HiguchiGenji Imokawa
Jan 17, 2004·Chemistry and Physics of Lipids·Dong-Seok KimKyoung-Chan Park
Apr 3, 2004·Cancer Research·Claudia WellbrockRichard Marais
Dec 1, 2004·Annual Review of Genetics·Eiríkur SteingrímssonNancy A Jenkins

❮ Previous
Next ❯

Citations

Jul 10, 2007·Archives of Pharmacal Research·Dong-Seok KimKyoung-Chan Park
Jan 8, 2010·The Journal of Biological Chemistry·Barbara BelleiMauro Picardo
Jun 19, 2007·Biochemistry. Biokhimii︠a︡·E V Dyatlovitskaya
May 7, 2008·The American Journal of Chinese Medicine·Jin BuCheng-Rang Li
Aug 16, 2011·Journal of Biomedical Science·Hyo-Soon JeongDong-Seok Kim
Sep 3, 2013·Biological & Pharmaceutical Bulletin·Hyo-Soon JeongDong-Seok Kim
Oct 30, 2009·International Journal of Molecular Sciences·Jody P EbanksRaymond E Boissy
Jul 1, 2008·Experimental & Molecular Medicine·Jeung-Hyun KooJin-Woo Park
Jun 18, 2015·Annals of Dermatology·Myoung Shin KimSung Eun Chang
Sep 28, 2010·Journal of Dermatological Science·Mi Yoon KimTae-Jin Yoon
Jan 16, 2007·The Journal of Investigative Dermatology·Hideya AndoVincent J Hearing
Apr 27, 2007·The Journal of Investigative Dermatology·Richard A NewtonRichard A Sturm
Aug 12, 2008·Clinics in Dermatology·Xing-Hua GaoHong-Duo Chen
Nov 23, 2007·Experimental Dermatology·Mitsuko KawanoHiroko Isoda
Nov 7, 2006·Pigment Cell Research·Francisco SolanoGhanem Ghanem
Dec 21, 2010·Experimental Dermatology·Ju Eun LeeDong-Seok Kim
May 18, 2011·Phytotherapy Research : PTR·Cai-Xia TuYun-Ying Zhang
Jul 3, 2013·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Yun-Mi JeongDong-Seok Kim
May 22, 2010·The Journal of Pharmacy and Pharmacology·Dong-Seok KimKyoung-Chan Park
Jun 20, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Hwayong ParkJin Yeul Ma
Apr 11, 2013·Pharmaceutical Biology·Jin-Ming HwangErl-Shyh Kao
Jan 2, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hsiu-Mei ChiangKuo-Ching Wen
Sep 10, 2013·European Journal of Pharmacology·Eun-Hyun KimDong-Seok Kim
Jan 22, 2015·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Yu Seok SongDong-Seok Kim
Jul 1, 2014·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Hailan LiDong-Seok Kim
Sep 2, 2014·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Mi-Ja AhnDong-Seok Kim
Jan 28, 2016·Expert Opinion on Therapeutic Patents·Sultan UllahHyung Ryong Moon
May 8, 2013·Biological & Pharmaceutical Bulletin·Do Hyun LeeMyeung Nam Kim
Mar 30, 2019·Experimental Dermatology·Chuhan FuQinghai Zeng
Jun 22, 2014·The Journal of Biological Chemistry·Heesung ChungEok-Soo Oh
Oct 24, 2017·International Journal of Cosmetic Science·E G Brunt, J G Burgess
Aug 30, 2020·Cells·Lorry CarriéNathalie Andrieu-Abadie
May 1, 2012·Molecular and Cellular Biochemistry·Hyo-Soon JeongDong-Seok Kim
Jun 28, 2019·Mini Reviews in Medicinal Chemistry·Kamal Uddin ZaidiIshrat Naaz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.