Oct 1, 2015

Sphinx: modeling transcriptional heterogeneity in single-cell RNA-Seq

BioRxiv : the Preprint Server for Biology
Jinghua GuWei Lin

Abstract

The significance of single cell transcription resides not only in the cumulative expression strength of the cell population but also in its heterogeneity. We propose a new model that improves the detection of changes in the transcriptional heterogeneity pattern of RNAseq data using two heterogeneity parameters: "burst proportion" and "burst magnitude", whose changes are validated using RNA FISH. Transcriptional "cobursting" governed by distinct mechanisms during myoblast proliferation and differentiation, is described here.

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Mentioned in this Paper

Fluorescent in Situ Hybridization
Sequence Determinations, RNA
Transcription, Genetic
Cell Differentiation Process
Myoblast Proliferation
Population Group
Sphinx
RNA
Gene Feature
Protein Expression

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