Spider peptide toxin lycosin-I induces apoptosis and inhibits migration of prostate cancer cells

Experimental Biology and Medicine
Hongwei ShenRongrong Cui

Abstract

Spider toxins are molecularly diverse and some display not only a strong antibacterial effect but also exhibit significant inhibition of tumor growth and promote tumor cell apoptosis. The aim of the present investigation was to explore different antitumor effects of the spider peptide toxin lycosin-I through different pathways at different concentrations. It was found that by inactivating STAT3 pathway, high concentrations of lycosin-I induce apoptosis in prostate cancer cells and low concentrations of lycosin-I inhibit the migration of prostate cancer cells. This finding provides favorable evidence for further study of the molecular diversity of spider toxins. Impact statement The spider peptide toxin has become an important research topic. These toxins are molecularly diverse and some display not only a strong antibacterial effect but also exhibit significant inhibition of tumor growth and promote tumor cell apoptosis. Inspired by previous studies, the present study aims to investigate the effects of different concentrations of lycosin-I on the invasiveness and apoptosis of human prostate cancer cells. The findings provide favorable evidence for further study of the molecular diversity of spider toxins.

References

Nov 5, 1999·The Journal of Pathology·S Curran, G I Murray
Jun 1, 2000·The Journal of Biological Chemistry·P EscoubasM Lazdunski
Jun 13, 2000·Oncogene·T E SmithgallM B Wilson
Mar 17, 2004·Journal of Cell Science·Jason S RawlingsDouglas A Harrison
Aug 12, 2005·Nature·L Revell PhillipsKenton J Swartz
Oct 13, 2006·Archiv der Pharmazie·Juan LiPing Gong
May 17, 2008·The American Journal of Pathology·Junaid AbdulghaniMarja T Nevalainen
Mar 20, 2012·European Urology·Melissa M CenterFreddie Bray
Oct 2, 2012·Annual Review of Entomology·Glenn F King, Margaret C Hardy

❮ Previous
Next ❯

Methods Mentioned

BETA
PCA
ELISA
PCR
xenograft

Software Mentioned

SPSS

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.