Spike and wave complexes produced by four hallucinogenic compounds in the cat

Physiology & Behavior
C M ContrerasR Palmour

Abstract

The ability of four hallucinogenic compounds: ketamine, phencyclidine, quipazine and SKF-10,047 to produce spike and wave activity in the limbic system, was studied in cats with permanently implanted electrodes. Electronic frequency integrators were used to analyze the results and the percent of change in electrographic alterations was calculated. All the compounds studied, produced trains of 6/sec spike and waves complexes in the cingulum, rapid synchronous discharges in the amygdaloid complex, and slow wave synchronous activity and spiking in the septal areas. At low but hallucinatory concentrations of these drugs, the cortical EEG was not affected. Exploratory movements directed toward non-existent objects, classified as hallucinatory-like behavior, appeared simultaneous with these changes in the EEG recordings. It was concluded that there could exist a relationship between the appearance of 6/sec spike and wave complexes in the cingulum and the presence of hallucinations, produced by some synthetic drugs in the cat, this activity could be interpreted as the spreading of altered function of limbic and non-limbic nuclei related with this bundle which explain unspecificity of action.

References

Mar 1, 1979·Electroencephalography and Clinical Neurophysiology·C M ContrerasA Fernández-Guardiola
Oct 1, 1974·Electroencephalography and Clinical Neurophysiology·G G Celesia, R C Chen
Dec 1, 1981·Physiology & Behavior·C M ContrerasR Palmour
Dec 1, 1963·Electroencephalography and Clinical Neurophysiology·D A POLLENK H REID

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Citations

Jan 1, 1990·Psychopharmacology·L L WingM A Geyer
Dec 1, 1986·Journal of Ethnopharmacology·L MayagoitiaC M Contreras
May 1, 1998·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·C M ContrerasM Vázquez-Torres
Jun 1, 1986·Experimental Neurology·C M ContrerasC Guzmán-Flores
Aug 7, 2004·Brain Research. Brain Research Reviews·Teige P SheehanDavid S Russell

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