Spike-evoked suppression and burst patterning in dorsal root ganglion neurons of the rat

The Journal of Physiology
R Amir, M Devor

Abstract

1. A low level of spontaneous impulse discharge is generated within dorsal root ganglia (DRGs) in intact animals, and this activity is enhanced following nerve injury. Many physiological stimuli present in vivo are capable of augmenting this ectopic discharge. Whatever their cause, episodes of sharply accelerated DRG firing tend to be followed by 'after-suppression' during which discharge falls below baseline rate. In this study we examined the process of postexcitation suppression of firing rate, and how it shapes spike patterning in primary sensory neurons. 2. We recorded intracellularly from sensory neurons in excised rat DRGs in vitro. Trains of spikes triggered by intracellular current pulses evoked a prolonged hyperpolarizing shift. This shift appeared to be due to activation of a Ca(2+)-dependent K+ conductance (9K(Ca)). Spikes evoked by just-suprathreshold pulses triggered a hyperpolarizing shift and spike cessation. As the shift decayed, spiking was restored. The net result was bursty (on-off) discharge, a previously unexplained peculiarity of ectopic discharge in some DRG neurons in vivo. 3. Conditioning nerve tetani delivered to axons of neurons which share the DRG with the impaled neuron evoked transient depolarizat...Continue Reading

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Citations

Feb 13, 1999·Progress in Neurobiology·M J Millan
Oct 27, 2001·Biosensors & Bioelectronics·R D HealA T Parsons
Jan 23, 2002·The Clinical Journal of Pain·Marshall DevorZ Harry Rappaport
Mar 11, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ron AmirMarshall Devor
Jul 12, 2014·Cell and Tissue Research·Anna M Hagenston, Manuela Simonetti
Jan 1, 2007·Journal of the Japanese Physical Therapy Association = Rigaku Ryōhō·Michael Ogbonnia EgwuMatthew Olatokumbo B Olaogun
Nov 23, 2006·The Journal of Pain : Official Journal of the American Pain Society·Amy M RitterWilliam J Martin
Apr 25, 2006·The Journal of Pain : Official Journal of the American Pain Society·Ron AmirGary R Strichartz
Apr 17, 2014·Antioxidants & Redox Signaling·Nikita Gamper, Lezanne Ooi
Apr 5, 2017·The Journal of Clinical Investigation·Xiaona DuNikita Gamper
Dec 28, 2002·Anesthesiology·J Bruce McCallumQuinn H Hogan
Aug 12, 2017·British Journal of Pharmacology·Xiaona DuNikita Gamper
Sep 4, 2015·Journal of Neurophysiology·Danielle SundtDavid B Jaffe
Sep 14, 1999·Journal of Neurophysiology·C M PedroarenaF R Morales
Feb 15, 2002·Brain : a Journal of Neurology·Ron AmirMarshall Devor
Jul 23, 2019·Neurosurgery·Philippe MagownKim J Burchiel
May 18, 2004·Neuroscience·M M ZareiE W McCleskey
Jun 22, 2021·Frontiers in Molecular Neuroscience·Deepanjali Dwivedi, Upinder S Bhalla

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