Spike-frequency adaptation of a generalized leaky integrate-and-fire model neuron

Journal of Computational Neuroscience
Y H Liu, X J Wang

Abstract

Although spike-frequency adaptation is a commonly observed property of neurons, its functional implications are still poorly understood. In this work, using a leaky integrate-and-fire neural model that includes a Ca2+-activated K+ current (IAHP), we develop a quantitative theory of adaptation temporal dynamics and compare our results with recent in vivo intracellular recordings from pyramidal cells in the cat visual cortex. Experimentally testable relations between the degree and the time constant of spike-frequency adaptation are predicted. We also contrast the IAHP model with an alternative adaptation model based on a dynamical firing threshold. Possible roles of adaptation in temporal computation are explored, as a a time-delayed neuronal self-inhibition mechanism. Our results include the following: (1) given the same firing rate, the variability of interspike intervals (ISIs) is either reduced or enhanced by adaptation, depending on whether the IAHP dynamics is fast or slow compared with the mean ISI in the output spike train; (2) when the inputs are Poisson-distributed (uncorrelated), adaptation generates temporal anticorrelation between ISIs, we suggest that measurement of this negative correlation provides a probe to ass...Continue Reading

Citations

Jul 23, 2020·Frontiers in Human Neuroscience·Scott O MurrayRaphael A Bernier
Oct 28, 2003·Neural Computation·Jan Benda, Andreas V M Herz
Feb 11, 2005·Journal of Neurophysiology·Gustavo Deco, Edmund T Rolls
Mar 23, 2006·Journal of Neurophysiology·Ramana DodlaJohn Rinzel
Dec 7, 2006·Bulletin of Mathematical Biology·Stefan ReinkerRachel Kuske
Nov 20, 2009·Neural Computation·Bryan P Tripp, Chris Eliasmith
Jan 27, 2011·Experimental Brain Research·Oscar Avila-Akerberg, Maurice J Chacron
Dec 7, 2010·Proceedings of the National Academy of Sciences of the United States of America·William H NesseAndré Longtin
Nov 1, 2013·Journal of Neurophysiology·Josef LadenbauerKlaus Obermayer
May 15, 2013·Discrete and Continuous Dynamical Systems. Series a·Xiangying MengJohn Rinzel
Jan 29, 2014·Journal of Computational Neuroscience·A V ChizhovA V Zaitsev
May 6, 2015·Journal of Computational Neuroscience·Tilo SchwalgerBenjamin Lindner
Apr 18, 2016·Journal of Computational Neuroscience·Ryota Kobayashi, Katsunori Kitano
Apr 20, 2017·PLoS Computational Biology·Tilo SchwalgerWulfram Gerstner
Apr 11, 2018·International Journal of Neural Systems·Jason K EshraghianKamran Eshraghian
Aug 8, 2019·Journal of the Royal Society, Interface·Marie LevakovaRyota Kobayashi
May 17, 2003·Journal of Neurophysiology·Alexander RauchStefano Fusi
Jul 9, 2004·Journal of Neurophysiology·Raymon M Glantz, John P Schroeter
Jan 2, 2004·Journal of Neurophysiology·Charles J WilsonMark D Bevan
Aug 31, 2004·Neural Computation·Giancarlo La CameraStefano Fusi
Apr 5, 2005·Nature Neuroscience·Maurice J ChacronJoseph Bastian
Apr 17, 2007·Journal of Computational Neuroscience·Maurice J ChacronAndré Longtin
Nov 30, 2007·Neural Computation·Sophie Deneve
May 15, 2013·Neural Computation·Andreas Steimer, Rodney Douglas
Mar 10, 2012·Journal of Neurophysiology·Avner Wallach, Shimon Marom
Jul 20, 2014·Biological cybernetics·Felix Droste, Benjamin Lindner
Jan 24, 2015·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Moritz DegerWulfram Gerstner
Mar 25, 2014·Theoretical Biology & Medical Modelling·Hui RenPu-Ming Zhang
Jun 18, 2015·Frontiers in Computational Neuroscience·Douglas L JonesRama Ratnam
Aug 26, 2014·Nature Neuroscience·Travis MeyerCarl R Olson
Jan 15, 2016·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Tilo Schwalger, Benjamin Lindner
Sep 30, 2016·Frontiers in Neuroscience·James C Knight, Steve B Furber
Jun 18, 2017·Physical Review. E·Wilhelm BraunAndré Longtin
Sep 6, 2017·PLoS Computational Biology·Abed GhanbariIan H Stevenson
Jun 9, 2018·Journal of Computational Neuroscience·Shigeru Kubota, Jonathan E Rubin

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