Spike persistence and normalization in benign epilepsy with centrotemporal spikes - Implications for management

Brain & Development
Hunmin KimDennis J Dlugos

Abstract

This study was performed 1) to determine the timing of spike normalization in patients with benign epilepsy with centrotemporal spikes (BECTS); 2) to identify relationships between age of seizure onset, age of spike normalization, years of spike persistence and treatment; and 3) to assess final outcomes between groups of patients with or without spikes at the time of medication tapering. Retrospective analysis of BECTS patients confirmed by clinical data, including age of onset, seizure semiology and serial electroencephalography (EEG) from diagnosis to remission. Age at spike normalization, years of spike persistence, and time of treatment onset to spike normalization were assessed. Final seizure and EEG outcome were compared between the groups with or without spikes at the time of AED tapering. One hundred and thirty-four patients were included. Mean age at seizure onset was 7.52 ± 2.11 years. Mean age at spike normalization was 11.89 ± 2.11 (range: 6.3-16.8) years. Mean time of treatment onset to spike normalization was 4.11 ± 2.13 (range: 0.24-10.08) years. Younger age of seizure onset was correlated with longer duration of spike persistence (r = -0.41, p < 0.001). In treated patients, spikes persisted for 4.1 ± 1.95 years,...Continue Reading

Citations

Mar 17, 2021·Seizure : the Journal of the British Epilepsy Association·Hasan TekgulSanem Yılmaz
Aug 14, 2021·International Medical Case Reports Journal·Olga AnSteven Parrish Winesett
Oct 16, 2020·Seizure : the Journal of the British Epilepsy Association·Wei GuChunfeng Wu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Benign Rolandic Epilepsy

Benign Rolandic epilepsy is a partial idiopathic epilepsy of childhood presenting with a nocturnal seizure and with a typical EEG showing centrotemporal spike and multifocal or generalized sharp slow waves. Here is the latest research.

© 2022 Meta ULC. All rights reserved