Spike protein recognition of mammalian ACE2 predicts the host range and an optimized ACE2 for SARS-CoV-2 infection

Biochemical and Biophysical Research Communications
Junwen LuanLeiliang Zhang


SARS-CoV-2 causes the recent global COVID-19 public health emergency. ACE2 is the receptor for both SARS-CoV-2 and SARS-CoV. To predict the potential host range of SARS-CoV-2, we analyzed the key residues of ACE2 for recognizing S protein. We found that most of the selected mammals including pets (dog and cat), pangolin and Circetidae mammals remained the most of key residues for association with S protein from SARS-CoV and SARS-CoV-2. The interaction interface between cat/dog/pangolin/Chinese hamster ACE2 and SARS-CoV/SARS-CoV-2 S protein was simulated through homology modeling. We identified that N82 in ACE2 showed a closer contact with SARS-CoV-2 S protein than M82 in human ACE2. Our finding will provide important insights into the host range of SARS-CoV-2 and a new strategy to design an optimized ACE2 for SARS-CoV-2 infection.


Jul 4, 2020·Journal of Medical Virology·Satarudra Prakash SinghThakur Prasad Yadav
May 3, 2020·British Journal of Pharmacology·Steve P H AlexanderMichael Spedding
Jul 1, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Giuseppe LippiFabian Sanchis-Gomar
Apr 3, 2020·Journal of Medical Virology·Junwen LuanLeiliang Zhang
Aug 7, 2020·Transboundary and Emerging Diseases·Shan GaoLeiliang Zhang
Jun 6, 2020·Human Genomics·Cathleen LutzWonyoung Kang
Jun 24, 2020·Proceedings of the National Academy of Sciences of the United States of America·Masaki ImaiYoshihiro Kawaoka
Jul 14, 2020·Virusdisease·Dinesh Kumar RajendranDharun Kasilingam
Aug 25, 2020·Medicinal Chemistry Research : an International Journal for Rapid Communications on Design and Mechanisms of Action of Biologically Active Agents·P Chellapandi, S Saranya
Jun 24, 2020·Pathogens·Marta HernándezDavid Rodríguez-Lázaro
Aug 1, 2020·Frontiers in Public Health·Lianzhou HuangYifei Wang
Jul 3, 2020·Frontiers in Immunology·Luis F García
Aug 21, 2020·Mucosal Immunology·M D JohansenP M Hansbro
Aug 23, 2020·Proceedings of the National Academy of Sciences of the United States of America·Joana DamasHarris A Lewin
Aug 8, 2020·Journal of Clinical Medicine·Ida GagliardiMichele Andreucci
Jun 11, 2020·Genetics and Molecular Biology·Fam Bibiana S OMaria Cátira Bortolini
Jul 17, 2020·International Journal of Molecular Sciences·Markus BlaessHans-Peter Deigner
Sep 29, 2020·Transboundary and Emerging Diseases·Saverio PaltrinieriStefania Lauzi
Oct 11, 2020·Vaccines·Nongluk Sriwilaijaroen, Yasuo Suzuki
Oct 27, 2020·Frontiers in Microbiology·Jie ZhaoBao-Ping Tian
Oct 23, 2020·Journal of Medical Virology·Chithra C SreenivasanFeng Li
Oct 22, 2020·Chembiochem : a European Journal of Chemical Biology·Jones de AndradePaulo Augusto Netz
Dec 8, 2020·Briefings in Bioinformatics·Senbiao FangMin Li
Dec 12, 2020·Expert Review of Anti-infective Therapy·Hin Fung TsangSze-Chuen Cesar Wong
Dec 21, 2020·Briefings in Bioinformatics·Pratik GoswamiVáclav Brázda
Dec 29, 2020·Frontiers in Molecular Biosciences·Yixin XieLin Li
May 12, 2020·International Journal of Antimicrobial Agents·Ran YuPeng Li
Dec 11, 2020·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Rasel AhmedMd Shahidul Islam
Dec 8, 2020·Computational and Structural Biotechnology Journal·Shan Gao, Leiliang Zhang

❮ Previous
Next ❯

Software Mentioned


Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.