Spike suppression in a local cortical circuit induced by transcranial magnetic stimulation.

Journal of Computational Neuroscience
Yoichi MiyawakiMasato Okada

Abstract

Transcranial magnetic stimulation (TMS) noninvasively interferes with human cortical function, and is widely used as an effective technique for probing causal links between neural activity and cognitive function. However, the physiological mechanisms underlying TMS-induced effects on neural activity remain unclear. We examined the mechanism by which TMS disrupts neural activity in a local circuit in early visual cortex using a computational model consisting of conductance-based spiking neurons with excitatory and inhibitory synaptic connections. We found that single-pulse TMS suppressed spiking activity in a local circuit model, disrupting the population response. Spike suppression was observed when TMS was applied to the local circuit within a limited time window after the local circuit received sensory afferent input, as observed in experiments investigating suppression of visual perception with TMS targeting early visual cortex. Quantitative analyses revealed that the magnitude of suppression was significantly larger for synaptically-connected neurons than for isolated individual neurons, suggesting that intracortical inhibitory synaptic coupling also plays an important role in TMS-induced suppression. A conventional local c...Continue Reading

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Citations

Oct 22, 2015·Experimental Brain Research·Sarah N KraeutnerShaun G Boe
Jul 11, 2014·Neuroscience and Biobehavioral Reviews·Tom A de GraafAlexander T Sack

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