Aug 21, 2010

Spike timing-dependent plasticity as the origin of the formation of clustered synaptic efficacy engrams

Frontiers in Computational Neuroscience
Nicolangelo IannellaShigeru Tanaka

Abstract

Synapse location, dendritic active properties and synaptic plasticity are all known to play some role in shaping the different input streams impinging onto a neuron. It remains unclear however, how the magnitude and spatial distribution of synaptic efficacies emerge from this interplay. Here, we investigate this interplay using a biophysically detailed neuron model of a reconstructed layer 2/3 pyramidal cell and spike timing-dependent plasticity (STDP). Specifically, we focus on the issue of how the efficacy of synapses contributed by different input streams are spatially represented in dendrites after STDP learning. We construct a simple feed forward network where a detailed model neuron receives synaptic inputs independently from multiple yet equally sized groups of afferent fibers with correlated activity, mimicking the spike activity from different neuronal populations encoding, for example, different sensory modalities. Interestingly, ensuing STDP learning, we observe that for all afferent groups, STDP leads to synaptic efficacies arranged into spatially segregated clusters effectively partitioning the dendritic tree. These segregated clusters possess a characteristic global organization in space, where they form a tessell...Continue Reading

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Mentioned in this Paper

Neurons
Pyramidal Cell of Cerebral Cortex
Synapses
Neuronal
Dendritic Tree
Pyramidal Cells
Dendrites
Mosaic Organism
Tissue Fiber

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