Spike-timing in primary sensory neurons: a model of somatosensory transduction in the rat

Biological cybernetics
Ben MitchinsonTony J Prescott

Abstract

In previous work, we constructed a simple electro-mechanical model of transduction in the rat mystacial follicle that was able to replicate primary afferent response profiles to a variety of whisker deflection stimuli. Here, we update that model to fit newly available spike-timing response data, and demonstrate that the new model produces appropriate responses to richer stimuli, including pseudo white noise and natural textures, at a spike-timing level of detail. Additionally, we demonstrate reliable distributed encoding of multi-component oscillatory signals. No modifications were necessary to the mechanical model of the physical components of the follicle-sinus complex, supporting its generality. We conclude that this model, and its continued development, will aid the understanding both of somatosensory systems in general, and of physiological results from higher (e.g. thalamocortical) systems by accurately characterising the signals on which they operate.

References

May 1, 1975·Journal of Neurophysiology·R W Dykes
Jan 1, 1990·Somatosensory & Motor Research·S H LichtensteinD J Simons
Dec 1, 1973·The Journal of Physiology·K M GottschaldtD W Young
Oct 9, 1981·Science·K M Gottschaldt, C Vahle-Hinz
Jul 1, 1994·Journal of Neurophysiology·H T KyriaziD J Simons
Apr 10, 1999·Neuron·M Meister, M J Berry
Mar 11, 2000·Journal of Neurophysiology·D J PintoD J Simons
Mar 28, 2002·Mathematical Biosciences·Sliman Bensmaïa
Jan 11, 2003·Journal of Neurophysiology·Brandon S Minnery, Daniel J Simons
Jun 6, 2003·Journal of Neurophysiology·Daniel R RobichaudPeter Grigg
Dec 4, 2003·Neuron·Marcin SzwedEhud Ahissar
Jan 27, 2004·Neuron·Samar B Mehta, David Kleinfeld
Mar 5, 2004·Journal of Neurophysiology·Lauren M JonesAsaf Keller
Dec 14, 2004·Proceedings. Biological Sciences·Ben MitchinsonTony J Prescott
Dec 23, 2004·The Journal of Physiology·Paul A Rhodes, Rodolfo Llinás
Jan 22, 2005·PLoS Biology·Ehsan ArabzadehMathew E Diamond
Jul 14, 2006·Current Opinion in Neurobiology·David KleinfeldMathew E Diamond
Mar 1, 1976·Neuroscience Letters·H Van Der Loos

❮ Previous
Next ❯

Citations

Jul 9, 2010·Journal of Neurophysiology·Sung Soo KimSliman J Bensmaia
Oct 14, 2011·Journal of Neurophysiology·Wendy A FriedmanAsaf Keller
Jan 29, 2010·PloS One·Stuart P WilsonJames A Bednar
Jul 19, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael R BaleRasmus S Petersen
Jun 29, 2010·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Sebastian HaidarliuEhud Ahissar
Jun 12, 2012·Progress in Neurobiology·Mathew E Diamond, Ehsan Arabzadeh
Jun 5, 2016·Journal of Biomechanics·Facundo Adrián LuciannaCarmelo José Felice
Apr 10, 2015·Journal of Neurophysiology·Samuel J WhiteleyDavid Kleinfeld

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.