Spiking and nonspiking models of starburst amacrine cells in the rabbit retina

Visual Neuroscience
T J Velte, R F Miller

Abstract

The integrative properties of starburst amacrine cells in the rabbit retina were studied with compartmental models and computer-stimulation techniques. The anatomical basis for these simulations was provided by computer reconstructions of intracellularly stained starburst amacrine cells and published data on dendritic diameter and biophysical properties. Passive and active membrane properties were included to simulate spiking and nonspiking behavior. Simulated synaptic inputs into one or more compartments consisted of a bipolar-like conductance change with peak and steady-state components provided by the sum of two Gaussian responses. Simulated impulse generation was achieved by using a model of impulse generation that included five nonlinear channels (INa, ICa, IA, IK, IK,Ca). The magnitude of the sodium channel conductance change was altered to meet several different types of impulse generation and propagation behaviors. We studied a range of model constraints which included variations in membrane resistance (Rm) from 4,000 omega.cm2 to 100,000 omega.cm2, and dendritic diameter from 0.1 to 0.3 micron. In a separate series of simulations, we studied the feasibility of voltage-clamping starburst amacrine cells using a soma-appl...Continue Reading

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Citations

Jul 10, 2003·Trends in Neurosciences·W Rowland Taylor, David I Vaney
Feb 9, 2012·Visual Neuroscience·W R Taylor, R G Smith
Sep 24, 2005·Journal of Integrative Neuroscience·Roman R Poznanski
Sep 29, 2011·Neuron·Alexander Borst, Thomas Euler
Sep 7, 2013·Journal of Physiology, Paris·María-José EscobarPatricio Orio
Dec 8, 2004·Visual Neuroscience·John J TukkerRobert G Smith
Oct 16, 2016·Journal of Medical Systems·Arezoo TahmasbiAli Rezaee
Feb 17, 2006·Journal of Neurophysiology·Robert F MillerToby J Velte
Feb 9, 2012·Nature Reviews. Neuroscience·David I VaneyW Rowland Taylor
Jan 14, 1999·The Journal of Comparative Neurology·L da F Costa, T J Velte
Oct 12, 2000·Journal of Neurophysiology·S WatanabeA Kaneko

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