Spiky Nanostructures with Geometry-matching Topography for Virus Inhibition

Nano Letters
Chuanxiong NieRainer Haag

Abstract

Geometry-matching has been known to benefit the formation of stable biological interactions in natural systems. Herein, we report that the spiky nanostructures with matched topography to the influenza A virus (IAV) virions could be used to design next-generation advanced virus inhibitors. We demonstrated that nanostructures with spikes between 5 and 10 nm bind significantly better to virions than smooth nanoparticles, due to the short spikes inserting into the gaps of glycoproteins of the IAV virion. Furthermore, an erythrocyte membrane (EM) was coated to target the IAV, and the obtained EM-coated nanostructures could efficiently prevent IAV virion binding to the cells and inhibit subsequent infection. In a postinfection study, the EM-coated nanostructures reduced >99.9% virus replication at the cellular nontoxic dosage. We predict that such a combination of geometry-matching topography and cellular membrane coating will also push forward the development of nanoinhibitors for other virus strains, including SARS-CoV-2.

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Citations

Sep 3, 2020·Nanomedicine·Georgia Wilson JonesBengt Fadeel
Dec 23, 2020·Smart Materials in Medicine·Chuanxiong NieChong Cheng
Mar 2, 2021·Advanced Materials·Si LiHua Kuang
Dec 20, 2020·Colloids and Surfaces. B, Biointerfaces·Tahereh Seifi, Ali Reza Kamali
Jun 4, 2021·Journal of Biological Physics·Vladimir P Zhdanov
Oct 13, 2021·ACS Applied Materials & Interfaces·Liying ZhaoDawei Deng

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