Spin column extraction as a new sample preparation method in bioanalysis

Bioanalysis
Akira Namera, Takashi Saito

Abstract

Sample preparation is important in obtaining accurate data for qualification and quantification in bioanalysis. We have recently focused on monolithic silica for high-throughput analysis. These extraction processes - using monolithic silica packed in spin column - such as sample loading, washing and elution, are executed by centrifugation. There are several possibilities such as on-column derivatization for the determination of amines or carboxylic acids in the sample. The spin column extraction reduces the sample preparation time required for determination of drugs and other chemicals in biological materials and increases productivity in bioanalysis. We expect spin column extraction to become the mainstream method of sample processing in the future.

References

Sep 10, 2004·Journal of Separation Science·Karin Cabrera
Apr 18, 2008·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Takeshi SaitoSadaki Inokuchi
Jul 29, 2008·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Takeshi SaitoSadaki Inokuchi
Mar 12, 2011·Journal of Separation Science·Akira NameraShota Miyazaki
Oct 12, 2011·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Takeshi SaitoSadaki Inokuchi
Nov 12, 2013·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Akira NameraMasataka Nagao

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