Spin trapping agent phenyl N-tert-butylnitrone protects against the onset of drug-induced insulin-dependent diabetes mellitus

FEBS Letters
T TabatabaieR A Floyd

Abstract

Insulin-dependent diabetes mellitus is an autoimmune disease believed to be caused by an inflammatory process in the pancreas leading to selective destruction of the beta-cells. Cytokines and nitric oxide (NO) have been shown to be involved in this destruction. Phenyl N-tert-butylnitrone (PBN) has demonstrated protective effects against several pathological conditions including ischemia-reperfusion injury and endotoxin-induced shock. We report here that PBN co-administration can prevent the onset of the STZ-induced diabetes in mice. PBN co-treatment inhibited the streptozotocin (STZ)-induced hyperglycemia, the elevation in the level of glycated hemoglobin and weight loss in the treated mice. Histological observations indicated destruction of B-cells in the STZ-treated animals and its prevention by PBN co-treatment. EPR spin trapping experiments in the pancreas indicated the in vivo formation of NO in STZ-treated animals and its attenuation by PBN treatment.

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Citations

Jul 24, 2010·Pflügers Archiv : European journal of physiology·Gisela DrewsMartina Düfer
Jun 5, 2002·Mechanisms of Ageing and Development·Robert A FloydPaul L Wood
Mar 10, 2001·Antioxidants & Redox Signaling·Y Kotake
Sep 17, 2008·Free Radical Biology & Medicine·Robert A FloydRheal A Towner
Apr 3, 2008·The Journal of Pharmacy and Pharmacology·Ki Sung KangTakako Yokozawa
Aug 23, 2011·Biotechnology Advances·Parmjit S Panesar, Shweta Kumari
Feb 24, 2006·Korean Journal of Ophthalmology : KJO·Jin Hyoung KimKyu-Won Kim
Apr 3, 2020·Journal of Cellular Physiology·Mohammad PanahiEffat Alizadeh
Apr 11, 2002·Chemical Reviews·Tetsuo Nagano, Tetsuhiko Yoshimura

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