Spinacia oleracea extract attenuates disease progression and sub-chondral bone changes in monosodium iodoacetate-induced osteoarthritis in rats

BMC Complementary and Alternative Medicine
Dharmendra ChoudharyRitu Trivedi

Abstract

Spinacia oleracea is an important dietary vegetable in India and throughout the world and has many beneficial effects. It is cultivated globally. However, its effect on osteoarthritis that mainly targets the cartilage cells remains unknown. In this study we aimed to evaluate the anti-osteoarthritic and chondro-protective effects of SOE on chemically induced osteoarthritis (OA). OA was induced by intra-patellar injection of monosodium iodoacetate (MIA) at the knee joint in rats. SOE was then given orally at 250 and 500 mg.kg- 1 day- 1 doses for 28 days to these rats. Anti-osteoarthritic potential of SOE was evaluated by micro-CT, mRNA and protein expression of pro-inflammatory and chondrogenic genes, clinically relevant biomarker's and behavioural experiments. In vitro cell free and cell based assays indicated that SOE acts as a strong anti-oxidant and an anti-inflammatory agent. Histological analysis of knee joints at the end of the experiment by safranin-o and toluidine blue staining established its protective effect. Radiological data corroborated the findings with improvement in the joint space and irregularity of the articular and atrophied femoral condyles and tibial plateau. Micro-CT analysis of sub-chondral bone indicate...Continue Reading

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Citations

Sep 25, 2019·International Journal of Molecular Sciences·Cleydlenne Costa VasconcelosMaria do Socorro de Sousa Cartágenes
Jun 5, 2019·Mini Reviews in Medicinal Chemistry·Rosa Martha Perez GutierrezSilvia Patricia Paredes Carrera
Aug 16, 2019·International Journal of Environmental Research and Public Health·Kok-Yong ChinSoelaiman Ima Nirwana
Oct 27, 2020·Current Rheumatology Reports·Marina Bañuls-MireteMonica Guma
Oct 27, 2020·Oxidative Medicine and Cellular Longevity·Małgorzata Kiełczykowska, Irena Musik

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Methods Mentioned

BETA
dissection
PCR
ELISA
enzyme-linked immunosorbent assay
MDA

Software Mentioned

Prism
BATMAN

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